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In this context, the hexane, dichloromethane, ethyl acetate and butanol fractions from the leaves of methanolic extract were analyzed by GC\/MS and HPLC\u2010DAD and the antioxidant potential was determined by DPPH and ABTS assays and using a <jats:italic>Saccharomyces cerevisiae<\/jats:italic> model. Dereplication allowed the identification of 68\u2005compounds, 42 and 41 of which, respectively, are first reported here for <jats:italic>E. copacabanensis<\/jats:italic> and <jats:italic>M. tenella. In vivo<\/jats:italic> results revealed that the ethyl acetate and butanol fractions showed expressive antioxidant protection in the BY4741 and <jats:italic>\u0394gsh1<\/jats:italic> strains, with greater impact on glutathione\u2010deficient cells. With a high diversity of phenolic compounds, these polar fractions of <jats:italic>E. copacabanensis<\/jats:italic> and <jats:italic>M. tenella<\/jats:italic> leaves are potential protectors against intracellular oxidative stress.<\/jats:p>","DOI":"10.1002\/cbdv.202100054","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T16:31:24Z","timestamp":1619713884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Determination of the Phytochemical Composition and Antioxidant Potential of <i>Eugenia copacabanensis<\/i> and <i>Myrciaria tenella<\/i> Leaves (Myrtaceae) Using a <i>Saccharomyces cerevisiae<\/i> Model"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-7189","authenticated-orcid":false,"given":"V\u00edctor","family":"de Carvalho Martins","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000 Brasil"},{"name":"Laborat\u00f3rio de Cromatografia L\u00edquida Embrapa Agroind\u00fastria de Alimentos  Rio de Janeiro RJ, 23020-470, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Princisval","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmim","family":"da Silva Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Cabral","family":"Pires","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estresse Oxidativo em Microrganismos Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"de Souza Cardoso","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estresse Oxidativo em Microrganismos Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Cristina","family":"Pessanha de Ara\u00fajo Santiago","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cromatografia L\u00edquida Embrapa Agroind\u00fastria de Alimentos  Rio de Janeiro RJ, 23020-470, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cromatografia L\u00edquida Embrapa Agroind\u00fastria de Alimentos  Rio de Janeiro RJ, 23020-470, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"da Costa Souza","sequence":"additional","affiliation":[{"name":"Herb\u00e1rio RBR Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano Jorge","family":"Riger","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estresse Oxidativo em Microrganismos Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronoel Luiz","family":"de Oliveira Godoy","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cromatografia L\u00edquida Embrapa Agroind\u00fastria de Alimentos  Rio de Janeiro RJ, 23020-470, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Geraldo de Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica de Produtos Naturais Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica RJ, 23897-000 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"706","article-title":"A Qu\u00edmica de Produtos Naturais do Brasil no S\u00e9culo XXI\u2019","volume":"40","author":"Berlinck R. 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