{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:26:29Z","timestamp":1789770389450,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study reports the <jats:italic>in\u2005vitro<\/jats:italic> anticoagulation activity of acetonic extract (AE) of 42 lichen species and the identification of potential bioavailable anticoagulant compounds from <jats:italic>Umbilicaria decussata<\/jats:italic> as a competent anticoagulant lichen species. Lichens\u2019 AEs were evaluated for their anticoagulant activity by monitoring activated partial thromboplastin time (APTT) and prothrombin time (PT) assays. A strong, positive correlation was observed between total phenolics concentration (TPC) of species and blood coagulation parameters. <jats:italic>U. decussata<\/jats:italic> was the only species with the longest clotting time in both APTT and PT assays. The research was moved forward by performing <jats:italic>in\u2005vivo<\/jats:italic> assays using rats. The results corroborated the dose\u2010dependent impact of <jats:italic>U. decussata<\/jats:italic>\u2019s AE on rats\u2019 clotting time. Major secondary metabolites of <jats:italic>U. decussata<\/jats:italic> and their plasma\u2010related bioavailability were also investigated using LC\u2010ESI\u2010MS\/MS. Atranol, orsellinic acid, D\u2010mannitol, lecanoric acid, and evernic acid were detected as possible bioavailable anticoagulants of <jats:italic>U. decussata<\/jats:italic>. Our findings suggest that <jats:italic>U. decussata<\/jats:italic> might be a potential anticoagulant lichen species that can be used for the prevention or treatment of coagulation\u2010related issues such as cardiovascular diseases (CVDs).<\/jats:p>","DOI":"10.1002\/cbdv.202100080","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T20:31:13Z","timestamp":1616790673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of <i>Umbilicaria decussata<\/i> as Potential Anticoagulants"],"prefix":"10.1002","volume":"18","author":[{"given":"Mohsen","family":"Vaez","sequence":"first","affiliation":[{"name":"Department of Biotechnology Iranian Research Organization for Science and Technology  Tehran Iran 3313193685"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-7242","authenticated-orcid":false,"given":"Seyed","family":"Javad Davarpanah","sequence":"additional","affiliation":[{"name":"Applied Biotechnology Research Center Baqiyatallah University of Medical Sciences  Tehran Iran 1435917341"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"crossref","unstructured":"V. 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