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In the present study, we evaluated these preparations for acute toxicity (1,000\u2005mg\/kg) and antinociceptive and anti\u2010inflammatory activities (100\u2013400\u2005mg\/kg for the extract and 25\u201350\u2005mg\/kg for the fraction). No signs of toxicity were observed. Both the extract and fraction increased the latency period for nociception in the hot plate assay, decreased writhing induced by acetic acid, and promoted analgesic effects in phases 1 and 2 of the formalin test. The antinociceptive mechanism was attributed to interactions with opioid receptors and K<jats:sup>+<\/jats:sup> ATPase channels. The extract and fraction decreased carrageenan\u2010induced paw edema in 46.15\u2009% and 77.22\u2009%, respectively, at the highest doses evaluated. Furthermore, the fraction was shown to act on the bradykinin pathway. The ability to decrease leukocyte migration after treatment was also verified in the peritonitis and air pouch models. In exudates collected from air pouches, decreased tumor necrosis factor (TNF)\u2010\u03b1 and increased interleukin (IL)\u201010 levels were noted. Both the extract and fraction also effectively inhibited the development of granulomatous tissue. In conclusion, the substances investigated in this study can be used for the development of novel therapeutic options for pain and inflammatory processes.<\/jats:p>","DOI":"10.1002\/cbdv.202100125","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T02:14:47Z","timestamp":1619230487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antinociceptive and Anti\u2010Inflammatory Effects of Saline Extract and Lectin\u2010Rich Fraction from <i>Microgramma vacciniifolia<\/i> Rhizome in Mice"],"prefix":"10.1002","volume":"18","author":[{"given":"Gabriela","family":"Cavalcante da Silva","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisson","family":"Mac\u00e1rio de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Felipe","family":"Soares de Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Maria Guedes","family":"Paiva","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2602","authenticated-orcid":false,"given":"Thiago Henrique","family":"Napole\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.06.015"},{"key":"e_1_2_7_2_1","first-page":"320","article-title":"Exerc\u00edcio f\u00edsico, processo inflamat\u00f3rio e adapta\u00e7\u00e3o: uma vis\u00e3o geral\u2019","volume":"13","author":"Silva F. 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