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Preliminary biological activity results showed that most of the compounds displayed significant inhibitory activities <jats:italic>in\u2005vitro<\/jats:italic> against <jats:italic>Xanthomonas axonopodis pv. Citri<\/jats:italic> (<jats:italic>X. axonopodis<\/jats:italic>), <jats:italic>Xanthomonas oryzae pv. oryzae<\/jats:italic> (<jats:italic>X. oryzae<\/jats:italic>) and <jats:italic>Ralstonia solanacearum<\/jats:italic> (<jats:italic>R. solanacearum<\/jats:italic>). In particular, compound\u20052\u2010[(3\u2010{[5,7\u2010dimethoxy\u20104\u2010oxo\u20102\u2010(3,4,5\u2010trimethoxyphenyl)\u20104<jats:italic>H<\/jats:italic>\u20101\u2010benzopyran\u20103\u2010yl]oxy}propyl)sulfanyl]\u20104\u2010(4\u2010methylphenyl)\u20106\u2010oxo\u20101,6\u2010dihydropyrimidine\u20105\u2010carbonitrile (<jats:bold>4c<\/jats:bold>) demonstrated a good inhibitory effect against <jats:italic>X. axonopodis<\/jats:italic> and <jats:italic>X. oryzae<\/jats:italic>, with the half\u2010maximal effective concentration (EC<jats:sub>50<\/jats:sub>) values of 15.5 and 14.9 \u03bcg\/mL, respectively, and compound\u20052\u2010[(3\u2010{[5,7\u2010Dimethoxy\u20104\u2010oxo\u20102\u2010(3,4,5\u2010trimethoxyphenyl)\u20104<jats:italic>H<\/jats:italic>\u20101\u2010benzopyran\u20103\u2010yl]oxy}propyl)sulfanyl]\u20104\u2010(3\u2010fluorophenyl)\u20106\u2010oxo\u20101,6\u2010dihydropyrimidine\u20105\u2010carbonitrile (<jats:bold>4h<\/jats:bold>) showed the best antibacterial activity against <jats:italic>R. solanacearum<\/jats:italic> with an EC<jats:sub>50<\/jats:sub> value of 14.7 \u03bcg\/mL. These results were better than commercial reagents bismerthiazol (BT, 51.7, 70.1 and 52.7 \u03bcg\/mL, respectively) and thiodiazole copper (TC, 77.9, 95.8 and 72.1 \u03bcg\/mL, respectively). <jats:italic>In vivo<\/jats:italic> antibacterial activity results indicated that compound\u2005<jats:bold>4c<\/jats:bold> displayed better curative (42.4\u2009%) and protective (49.2\u2009%) activities for rice bacterial leaf blight than BT (35.2, 39.1\u2009%) and TC (30.8, 27.3\u2009%). The mechanism of compound\u2005<jats:bold>4c<\/jats:bold> against <jats:italic>X. oryzae<\/jats:italic> was analyzed through scanning electron microscopy (SEM). These results indicated that pyrimidine\u2010containing 4<jats:italic>H<\/jats:italic>\u2010chromen\u20104\u2010one derivatives have important value in the research of new agrochemicals.<\/jats:p>","DOI":"10.1002\/cbdv.202100186","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:39:48Z","timestamp":1624423188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Design, Synthesis and Antibacterial Activity of Novel Pyrimidine\u2010Containing 4<i>H<\/i>\u2010Chromen\u20104\u2010One Derivatives**"],"prefix":"10.1002","volume":"18","author":[{"given":"Shijun","family":"Su","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Guizhou University  Guiyang 550025 P. R. 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