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Evaluation of the synthesized compounds revealed a good to excellent antioxidant activities (37.6\u201396.2\u2009%) using DPPH inhibitory potency. Among these compounds, hydantoin derivatives displayed higher antioxidant activities (93.7\u201396.2\u2009%) comparing with spiropyrazoles and pyrazoles. The obtained results showed that Cl and Br substituents on the phenyl ring increased antioxidant activities of the related heterocycles. The antibacterial activities of the synthesized compounds were examined against two Gram\u2010negative (<jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>) and two Gram\u2010positive (<jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Bacillus subtilis<\/jats:italic>) <jats:italic>bacteria<\/jats:italic>. Among the synthesized heterocycles, 2\u2010[1,3\u2010dimethyl\u20102,5\u2010dioxo\u20104\u2010(2\u2010oxo\u20102\u2010phenylethyl)imidazolidin\u20104\u2010yl]hydrazine\u20101\u2010carbothioamide exhibited the excellent antibacterial activity against both Gram\u2010positive and Gram\u2010negative bacteria.<\/jats:p>","DOI":"10.1002\/cbdv.202100197","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T10:29:53Z","timestamp":1626517793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Preparation of New Spiropyrazole, Pyrazole and Hydantoin Derivatives and Investigation of Their Antioxidant and Antibacterial Activities."],"prefix":"10.1002","volume":"18","author":[{"given":"Leila","family":"Ghasempour","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Faculty of Chemistry University of Mazandaran  Babolsar 47416-95447 Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-9525","authenticated-orcid":false,"given":"Sakineh","family":"Asghari","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Chemistry University of Mazandaran  Babolsar 47416-95447 Iran"},{"name":"Nano and Biotechnology Research Group University of Mazandaran  Babolsar 47416-95447 Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Tajbakhsh","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Chemistry University of Mazandaran  Babolsar 47416-95447 Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Nano and Biotechnology Research Group University of Mazandaran  Babolsar 47416-95447 Iran"},{"name":"Department of Microbiology Faculty of Science University of Mazandaran  Babolsar 47416-95447 Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"7479","article-title":"Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain\u2019","volume":"20","author":"Tyagarajan S.","year":"2010","journal-title":"Med. 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