{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:06:34Z","timestamp":1790870794362,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rehmanniae Radix Praeparata is the processed products of the root of <jats:italic>Rehmannia glutinosa<\/jats:italic>. It has been used as a Traditional Chinese Medicine for thousands of years, and it has been found to possess widely pharmacological activities. In this study, three new 2,2\u2032\u2010difurylketone derivatives (rehmanniaeketone A\u2013C) and two new chromones [3,8\u2010dihydroxy\u20102\u2010(2\u2010hydroxyethyl)chromone and 3,8\u2010dihydroxy\u20102\u2010[(2\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010D\u2010galactopyranosyloxy)ethyl]chromone] were isolated from the Rehmanniae Radix Praeparata. Furthermore all of the compounds were subjected to cytotoxic testing against the human lung carcinoma A549 cells. The cytotoxic results showed that rehmanniaeketone B and rehmanniaeketone C exhibited more stronger inhibition effects on the cell activity of A549 cells with the IC<jats:sub>50<\/jats:sub> 5.23\u2005\u03bcM and 2.05\u2005\u03bcM than other compounds. And 3,8\u2010dihydroxy\u20102\u2010(2\u2010hydroxyethyl)chromone exhibited moderately inhibitory activity with the IC<jats:sub>50<\/jats:sub> 61\u2005\u03bcM. Rehmanniaeketone A and 3,8\u2010dihydroxy\u20102\u2010[(2\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010D\u2010galactopyranosyloxy]chromone showed no inhibitory effects.<\/jats:p>","DOI":"10.1002\/cbdv.202100237","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T12:29:51Z","timestamp":1629116991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Three New 2,2\u2032\u2010Difurylketone Derivatives and Two New Chromones from the Rehmanniae Radix Praeparata"],"prefix":"10.1002","volume":"18","author":[{"given":"Jingke","family":"Zhang","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Lyu","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Shi","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Wie","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Zheng","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Feng","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Henan University of Chinese Medicine  Jin Shui Dong Road 156 Zhengzhou 450046 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"1923","article-title":"\u2018Comparison of the contents of three active components in the root of fresh Rehmannia glutinosa (xiandihuang), the root of Rehmannia glutinosa 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J.","year":"2008","journal-title":"Chin. J. Chin. Mat. Med."},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.05.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2013.07.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.958735"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200815192"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"\u2018Rehmannia glutinosa Libosch extracts prevent bone loss and architectural deterioration and enhance osteoblastic bone formation by regulating the IGF-1\/PI3\u2005K\/mTOR pathway in streptozotocin-induced diabetic rats\u2019","volume":"20","author":"Zhang Q.","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_7_7_1","first-page":"177","article-title":"\u2018Study on molecular mechanism of Shudihuang (Rehmanniae Radix Praeparata) in treating osteoporosis based on network pharmacology\u2019","volume":"39","author":"Feng P.","year":"2020","journal-title":"Shandong J. Tradit. Chin. Med."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.02.018"},{"key":"e_1_2_7_9_1","first-page":"289","article-title":"\u2018A new alkaloid from the Rehmanniae Radix Preparata\u2019","volume":"55","author":"Lyu J. J.","year":"2020","journal-title":"Acta. Pharm. Sin."},{"key":"e_1_2_7_10_1","first-page":"832","article-title":"\u2018Systemic therapy for stage IV non\u2013small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline update\u2019","volume":"33","author":"Masters G. A.","year":"2017","journal-title":"J. Clin. 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