{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:43:44Z","timestamp":1777326224734,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genus<jats:italic>Rhanterium<\/jats:italic>(Asteraceae) is a widely distributed medicinal plant throughout western North Africa and some<jats:italic>Rhanterium<\/jats:italic>species are used in folk medicine. The aim of research was to investigate methanolic extracts from different parts (flowers, leaves, and stems) of Tunisian<jats:italic>Rhanterium suaveolens<\/jats:italic>as potential sources of bioactive products useful for healthy purposes. In particular, were analyzed the phenolic composition of these extracts and their antioxidant, anti\u2010inflammatory, and anti\u2010tyrosinase properties.<\/jats:p><jats:p>The phytochemical analyses were performed using standard colorimetric procedures, HPLC\u2010DAD and HPLC\u2010DAD\u2010ESI\u2010MS. Then, several in\u2005vitro cell\u2010free assays have been used to estimate the antioxidant\/free radical scavenging capability of the extracts. Moreover,<jats:italic>in\u2005vitro<\/jats:italic>, and<jats:italic>in\u2005vivo<\/jats:italic>anti\u2010melanogenesis activities of these extracts were tested, respectively, with the tyrosinase inhibition assay and the Zebrafish embryo model. Finally, the anti\u2010inflammatory potential of these extracts in an<jats:italic>in\u2005vitro<\/jats:italic>model of acute intestinal inflammation in differentiated Caco\u20102 cells was evaluated.<\/jats:p><jats:p>The<jats:italic>R. suaveolens<\/jats:italic>extracts under study appeared particularly rich in flavonols and hydroxycinnamic acids and all extracts appeared endowed with good antioxidant\/free radical scavenging properties, being the flower extracts slightly more active than the others. Moreover,<jats:italic>R. suaveolens<\/jats:italic>flowers extract was able to inhibit in\u2005vitro tyrosinase activity and exhibited bleaching effects on the pigmentation of zebrafish embryos. Furthermore, all extracts showed good anti\u2010inflammatory activity in intestinal epithelial cells as demonstrated by the inhibition of TNF\u2010\u03b1\u2010induced gene expression of IL\u20106 and IL\u20108.<\/jats:p><jats:p><jats:italic>R. suaveolens<\/jats:italic>aerial parts may be considered as a potential source of whitening agents, as well as of agents for the treatment of disorders related to oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/cbdv.202100316","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T10:14:23Z","timestamp":1623406463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of Antioxidant, Anti\u2010Inflammatory and Antityrosinase Potential of Extracts from Different Aerial Parts of<i>Rhanterium suaveolens<\/i>from Tunisia"],"prefix":"10.1002","volume":"18","author":[{"given":"Sabrine","family":"Chelly","sequence":"first","affiliation":[{"name":"Toxicology-, Microbiology- and Environmental Health Laboratory (RL 17ES06) Faculty of Sciences University of Sfax 3000 Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryam","family":"Chelly","sequence":"additional","affiliation":[{"name":"Toxicology-, Microbiology- and Environmental Health Laboratory (RL 17ES06) Faculty of Sciences University of Sfax 3000 Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Occhiuto","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cimino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-9616","authenticated-orcid":false,"given":"Mariateresa","family":"Cristani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Saija","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Sofia","family":"Molonia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ruberto","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR) Via Paolo Gaifami, 18 95126 Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"German\u00f2","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Siracusa","sequence":"additional","affiliation":[{"name":"Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR) Via Paolo Gaifami, 18 95126 Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanen","family":"Bouaziz\u2010Ketata","sequence":"additional","affiliation":[{"name":"Toxicology-, Microbiology- and Environmental Health Laboratory (RL 17ES06) Faculty of Sciences University of Sfax 3000 Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Speciale","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali Universit\u00e0 di Viale Annunziata 98168 Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.990904"},{"key":"e_1_2_7_2_1","article-title":"Comparative Study for the Volatile Oil Constituents and Antimicrobial Activity of Rhanterium epapposum Oliv. Growing in Qassim, Saudi Arabia\u2019","volume":"11","author":"Mohammed H. A.","year":"2019","journal-title":"Pharmacogenomics J."},{"key":"e_1_2_7_3_1","first-page":"4002","article-title":"In vitro antioxidant activities of Rhantherium suaveolens extracts\u2019","volume":"8","author":"Amrani A.","year":"2017","journal-title":"J. Mater. Environ. Sci."},{"key":"e_1_2_7_4_1","first-page":"7017","article-title":"Polyphenols content, antioxidant and antimicrobial activities of extracts of some wild plants collected from the south of Tunisia\u2019","volume":"8","author":"Bouaziz M.","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.12.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2019.1624199"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1110705"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.10.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2019.101355"},{"key":"e_1_2_7_10_1","first-page":"146","article-title":"A review of quercetin: antioxidant and anticancer properties\u2019","volume":"1","author":"Baghel S. S.","year":"2012","journal-title":"World J. Pharm. Sci."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3020018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900428"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/221279680801141112095950"},{"key":"e_1_2_7_14_1","first-page":"6","article-title":"Medical importance of Anthemis nobilis (Chamaemelum nobile) \u2013 A review\u2019","volume":"6","author":"Al-Snafi A. E.","year":"2016","journal-title":"Asian J. Pharm. Sci."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.07.073"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1283494"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2016.07.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010514x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0485436"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13630"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955708784223486"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2016.1140093"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.3.597"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20160731025522"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3400539"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.04.018"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i41.5848"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/925219"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.326"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00042.2003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123873"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0674-4"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.100"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010130"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-017-0156-5"},{"key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3839\/jksabc.2011.091","article-title":"Antioxidant capacity and anti-inflammatory effect of the ethyl acetate fraction of dried persimmon (Diospyros kaki Thumb.) on THP-1 human acute monocytic leukemia cell lines\u2019","volume":"54","author":"Kim E. O.","year":"2011","journal-title":"J. Korean Soc. Appl. Biol. Chem."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-019-0421-y"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.07.010"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.05.184"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.157707"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-014-9814-x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.03.027"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00385059"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010186"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100185"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1012"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4019"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000345"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-006-0001-0"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.179"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.10.014"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3454023"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.10.030"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202100316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T20:08:31Z","timestamp":1699128511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202100316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/cbdv.202100316"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202100316","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"2021-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2100316"}}