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Their structure\u2010activity relationships were summarized. In particular, (2<jats:italic>E<\/jats:italic>)\u20103\u2010[4\u2010(dimethylamino)phenyl]\u20101\u2010(pyridin\u20102\u2010yl)prop\u20102\u2010en\u20101\u2010one (<jats:bold>3g<\/jats:bold>) exhibited an excellent inhibitory activity of 94.5\u2009% at 20\u2005\u03bcM, and it could disassemble the self\u2010induced A\u03b2<jats:sub>1\u201042<\/jats:sub> aggregation fibrils with ratio of 57.1\u2009% at 20\u2005\u03bcM concentration. In addition, compound <jats:bold>3g<\/jats:bold> displayed good chelating ability for Cu<jats:sup>2+<\/jats:sup>, and could effectively inhibit and disaggregate Cu<jats:sup>2+<\/jats:sup>\u2010induced A\u03b2 aggregation. Moreover, compound <jats:bold>3g<\/jats:bold> exerted low cytotoxicity, significantly reversed A\u03b2<jats:sub>1\u201042<\/jats:sub>\u2010induced SH\u2010SY5Y cell damage. More importantly, compound <jats:bold>3g<\/jats:bold> remarkably ameliorated scopolamine\u2010induced memory impairment in mice. In summary, all the results revealed compound <jats:bold>3g<\/jats:bold> was a potential multifunctional agent for AD therapy.<\/jats:p>","DOI":"10.1002\/cbdv.202100341","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:08:26Z","timestamp":1631470106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-5048","authenticated-orcid":false,"given":"Xiao\u2010Qin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Guangdong Medical University  Dongguan 523808 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Medical 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