{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:23Z","timestamp":1753862843639,"version":"3.41.2"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Spermacoce verticillata<\/jats:italic>(L.) G. Mey. is commonly used in the folk medicine by various cultures to manage common diseases. Herein, the chemical and biological profiles of<jats:italic>S.\u2005verticillata<\/jats:italic>were studied in order to provide a comprehensive characterization of bioactive compounds and also to highlight the therapeutic properties. The<jats:italic>in\u2005vitro<\/jats:italic>antioxidant activity using free\u2010radical scavenging, phosphomolybdenum, ferrous\u2010ion chelating and reducing power assays, and the inhibitory activity against key enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), tyrosinase, \u03b1\u2010amylase and \u03b1\u2010glucosidase of<jats:italic>S.\u2005verticillata<\/jats:italic>extracts (dichloromethane, ethyl acetate, methanol and water) were investigated. The highest total phenolic and flavonoid content were observed in the methanolic and aqueous extracts. Exhaustive 2DNMR investigation has revealed the presence of rutin, ursolic and oleanoic acids. The methanolic extract, followed by aqueous extract have showed remarkable free radical quenching and reducing ability, while the dichloromethane extract was the best source of metal chelators. The tested extracts showed notable inhibitory activity against cholinesterases (AChE: 1.63\u20134.99\u2005mg GALAE\/g extract and BChE: 12.40\u201315.48\u2005mg GALAE\/g extract) and tyrosinase (60.85\u2013159.64\u2005mg KAE\/g extract). No inhibitory activity was displayed by ethyl acetate and aqueous extracts against BChE and tyrosinase, respectively. All the tested extracts showed modest \u03b1\u2010amylase inhibitory activity, while only the ethyl acetate and aqueous extracts were potent against \u03b1\u2010glycosidase. This study further validates the use of<jats:italic>S.\u2005verticillata<\/jats:italic>in the traditional medicine, while advocating for further investigation for phytomedicine development.<\/jats:p>","DOI":"10.1002\/cbdv.202100371","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:17:26Z","timestamp":1628842646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biological Insights and NMR Metabolic Profiling of Different Extracts of<i>Spermacoce verticillata<\/i>(L.) G. Mey."],"prefix":"10.1002","volume":"18","author":[{"given":"Kouadio Ibrahime","family":"Sinan","sequence":"first","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory Department of Biology Science Faculty Selcuk University Campus Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory Department of Biology Science Faculty Selcuk University Campus Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche \u2013 DiSTABiF Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli' via Vivaldi 43 I-81100 Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigida","family":"D'Abrosca","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche \u2013 DiSTABiF Universit\u00e0 degli Studi della Campania \u2018Luigi Vanvitelli' via Vivaldi 43 I-81100 Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunes","family":"Ak","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory Department of Biology Science Faculty Selcuk University Campus Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devina","family":"Lobine","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Faculty of Medicine and Health Sciences University of Mauritius, R\u00e9duit Mauritius"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouattara Katinan","family":"Etienne","sequence":"additional","affiliation":[{"name":"Laboratoire de Botanique UFR Biosciences Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar Hussein","family":"Subratty","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Faculty of Medicine and Health Sciences University of Mauritius, R\u00e9duit Mauritius"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Faculty of Medicine and Health Sciences University of Mauritius, R\u00e9duit Mauritius"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010617-052703"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NJ00347E"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.26480\/msp.01.2017.17.26"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"M.\u2005M. 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