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Herein, chemical isolation was performed and four alkaloids were isolated from <jats:italic>Fuzi<\/jats:italic>, of which two were new ones, and the other two were reported NMR data for the first time. Their chemical structures were identified by NMR data, high resolution MS, UV and IR analysis. Additionally, the MS fragmentation patterns were explored, formerly, that of hetisane alkaloid was rarely reported, and fragmentation mechanism of the diagnostic ion was proposed. Based on these fragment pathway, metabolites and metabolic pathways of four compounds were investigated in rat liver microsomes using UPLC\u2212Q\/TOF\u2212MS, and dehydrogenation product was firstly found from metabolites of hetisane alkaloid.<\/jats:p>","DOI":"10.1002\/cbdv.202100388","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T05:52:08Z","timestamp":1628920328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two New Alkaloids from <i>Fuzi<\/i> and Their Metabolites Study"],"prefix":"10.1002","volume":"18","author":[{"given":"Sisi","family":"Liu","sequence":"first","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Deng","sequence":"additional","affiliation":[{"name":"Jiangxi Medical College Nanchang University  Nanchang, Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Long","sequence":"additional","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shushu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junshuo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangxi Medical College Nanchang University  Nanchang, Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunsheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjiangsheng","family":"Lai","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiran","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Resources Environmental &amp; Chemical Engineering Nanchang University  Nanchang 330031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b13786"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.11.043"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300225t"},{"key":"e_1_2_7_4_1","first-page":"69","article-title":"\u2018Revisions of the diterpenoid alkaloids reported in a JNP paper (2012,75,1145-1159)\u2019","author":"Zhang Z.","year":"2013","journal-title":"Tetrahedron"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03956"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104412"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2003.tb00121.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.066951"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1139\/v79-266"},{"key":"e_1_2_7_10_1","first-page":"42","article-title":"\u2018Effect of aqueous solution of Aconite on arrhythmia\u2019","volume":"13","author":"Shao L.","year":"1988","journal-title":"Bull. 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