{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:23:11Z","timestamp":1777292591846,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclophosphamide (CYP) is a widely used antineoplastic and immunosuppressive drug, however, despite its efficacy, it has shown extensive multiple organ toxicities, including peripheral neuropathy which significantly affects the quality of life of cancer patients. This study elucidated the protective properties of<jats:italic>Shorea roxburghii<\/jats:italic>polyphenol extract (SLPE) in CYP\u2010induced peripheral neuropathy. Rats were treated with SLPE (100 and 400\u2005mg\/kg) for five weeks plus CYP once a week from the second week of SLPE treatment. Using UHPLC\u2010QTOF\u2010MS, 54 polyphenolic compounds were identified in SLPE extract. After the treatment period the antinociceptive, anti\u2010hyperalgesia and antiallodynic effects was evaluated using formalin paw edema, acetic acid abdominal writhing, hot plate, tail immersion and von Frey filament tests. While the locomotive and motor coordination effects were evaluated by open field and rotarod tests. The administration of CYP led to significant increases in mechanical and thermal hyperalgesia, in addition to hyper\u2010nociceptive responses in the formalin and acetic acid writhing tests. CYP also significantly reduced locomotive activity and motor coordination. SLPE significantly protected against CYP\u2010induced mechanical and thermal hyperalgesia. Furthermore, SLPE displayed robust antinociceptive effect by counteracting formalin and acetic acid induced hyper\u2010nociception. In addition, SLPE increased the locomotive activity as well as the grip and motor coordination of the CYP treated rats. In conclusion, these results revealed the protective effects of SLPE against CYP\u2010induced peripheral neuropathy and could be an effective therapeutic remedy for chemotherapy induced peripheral neuropathy.<\/jats:p>","DOI":"10.1002\/cbdv.202100415","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T02:08:23Z","timestamp":1628561303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antinociceptive, Anti\u2010Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract from<i>Shorea roxburghii<\/i>against Cyclophosphamide Induced Peripheral Neuropathy"],"prefix":"10.1002","volume":"18","author":[{"given":"Haili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of the Second Anaesthesia Honghui Hospital Xi'an Jiaotong University Xi'an 710068 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opeyemi Joshua","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Faculty of Thai Traditional Medicine Prince of Songkla University Hat Yai 90110 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of the Second Anaesthesia Honghui Hospital Xi'an Jiaotong University Xi'an 710068 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102831"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118913"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000671"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2415-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/26895293.2021.1927204"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.02.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22313"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2015.1103827"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00109-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2018.09.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.211"},{"key":"e_1_2_7_12_1","first-page":"18","article-title":"\u2018Chemotherapy-induced neurotoxicity: the value of neuroprotective strategies\u2019","volume":"70","author":"Beijers A. J. M.","year":"2012","journal-title":"Neth. J. Med."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112266"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117876"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900661"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23043"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020451"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8467406"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587218757649"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S270038"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113883"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00003-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.115"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000090"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050941"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011232"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.108"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00174"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx267"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886314666190506100717"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207753"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/jbcpp-2015-0114","article-title":"\u2018Neuroprotective effect of Decalepis hamiltonii on cyclophosphamide-induced oxidative stress in the mouse brain\u2019","volume":"27","author":"Zarei M.","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090415"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2018.34.2.133"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109681"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2017.1318913"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.03.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118869"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1275704"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08618H"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1504058"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.004"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202100415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T04:41:44Z","timestamp":1699332104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202100415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/cbdv.202100415"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202100415","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"assertion":[{"value":"2021-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2100415"}}