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Also, <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were calculated from the Lineweaver\u2010Burk graphs. Some symmetric sulfamides compounds (<jats:bold>11<\/jats:bold>\u2013<jats:bold>18<\/jats:bold>) demonstrated excellent inhibition effects against <jats:italic>h<\/jats:italic>CA I, and II isoenzymes. These compounds demonstrated effective inhibitory profiles with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> values in ranging from 21.66\u201328.88\u2005nM against <jats:italic>h<\/jats:italic>CA I, 14.44\u201330.13\u2005nM against <jats:italic>h<\/jats:italic>CA II. Among these compounds, the best <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> value for <jats:italic>h<\/jats:italic>CA I (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 8.34\u00b11.60\u2005nM) and <jats:italic>h<\/jats:italic>CA II (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 16.40\u00b11.00\u2005nM) is compound number <jats:bold>11<\/jats:bold>. Besides, the <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> value of acetazolamide used as a standard was determined as <jats:italic>h<\/jats:italic>CA I, <jats:italic>h<\/jats:italic>CA II 57.75\u2005nM, 49.50\u2005nM, respectively. Moreover, in silico ADME\u2010Tox study showed that all synthesized compounds (<jats:bold>11<\/jats:bold>\u2013<jats:bold>18<\/jats:bold>) had good oral bioavailability in light of Jorgensen's rule of three, and of Lipinski's rule of five.<\/jats:p>","DOI":"10.1002\/cbdv.202100422","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T02:23:04Z","timestamp":1628821384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition Profiles of Some Symmetric Sulfamides Derived from Phenethylamines on Human Carbonic Anhydrase I, and II Isoenzymes"],"prefix":"10.1002","volume":"18","author":[{"given":"Fevzi","family":"Topal","sequence":"first","affiliation":[{"name":"Department of Chemical and Chemical Processing Technologies G\u00fcm\u00fc\u015fhane Vocational School G\u00fcm\u00fc\u015fhane University  G\u00fcm\u00fc\u015fhane 29100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Arts Ordu University  Ordu 52200 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhan","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Arts S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f 46100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"Goksu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"G. 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