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Aurones (<jats:bold>1<\/jats:bold>) and (<jats:bold>2<\/jats:bold>) promoted changes in tegument integrity and motor activity, leading to death of adult<jats:italic>Schistosoma mansoni<\/jats:italic>worms in<jats:italic>in\u2005vitro<\/jats:italic>assays. When administered orally (two doses of 50\u2005mg\/kg) in experimentally infected animals, synthetic aurones (<jats:bold>1<\/jats:bold>) and (<jats:bold>2<\/jats:bold>) promoted reductions of 56.20\u2009% and 57.61\u2009% of the parasite load and stimulated the displacement towards the liver of the remaining adult worms. The oogram analysis revealed that the treatment with both aurones interferes with the egg development kinetics in the intestinal tissue. Seeking an action target for compounds (<jats:bold>1<\/jats:bold>) and (<jats:bold>2<\/jats:bold>), the connection with NTPDases enzymes, recognized as important therapeutic targets for<jats:italic>S. mansoni<\/jats:italic>, was evaluated. Molecular docking studies have shown promising results. The dataset reveals the anthelmintic character of these compounds, which can be used in the development of new therapies for schistosomiasis.<\/jats:p>","DOI":"10.1002\/cbdv.202100439","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:48:09Z","timestamp":1634766489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthetic Aurones: New Features for<i>Schistosoma mansoni<\/i>Therapy"],"prefix":"10.1002","volume":"18","author":[{"given":"Daniel","family":"Silva Torres","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Juiz de Fora Juiz de Fora MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Alves de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias Biol\u00f3gicas 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