{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:42:45Z","timestamp":1790271765241,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the essential oil composition of five <jats:italic>Thymus<\/jats:italic> species, belonging to Sect. <jats:italic>Hyphodromi<\/jats:italic> (A. Kerner) Hal\u00e1csy \u2013 <jats:italic>Thymus atticus<\/jats:italic> \u010celak., <jats:italic>T. leucotrichus<\/jats:italic> Hal\u00e1csy, <jats:italic>T. striatus<\/jats:italic> Vahl, <jats:italic>T. zygioides<\/jats:italic> Griseb. and <jats:italic>T. perinicus<\/jats:italic> (Velen.) Jalas. was studied by GC\/MS\/FID. <jats:italic>T. atticus<\/jats:italic>, <jats:italic>T. leucotrichus<\/jats:italic>, and <jats:italic>T. striatus<\/jats:italic> were characterized by high amounts of sesquiterpenoids (57.7, 78.9 and 79.7\u2009%, respectively) with \u03b2\u2010caryophyllene and caryophyllene oxide as the main constituents. Aromatic compounds (61.2\u2009%) were the most abundant group in <jats:italic>T. zygioides<\/jats:italic> essential oil, with thymol (51.2\u2009%) as the principal component. The essential oil from the endemic species <jats:italic>T. perinicus<\/jats:italic> contained almost equal amounts of monoterpenoids (37.8\u2009%) and aromatic compounds (36.0\u2009%) with borneol (17.9\u2009%) and thymol (20.9\u2009%) as the major components. The obtained results revealed the existence of new chemotypes of <jats:italic>T. atticus<\/jats:italic> (caryophyllene oxide\/\u03b2\u2010caryophyllene), <jats:italic>T. leucotrichus<\/jats:italic> (\u03b2\u2010caryophyllene\/elemol\/germacrene D) and <jats:italic>T. striatus<\/jats:italic> (\u03b2\u2010caryophyllene\/germacrene D\/caryophyllene oxide). The essential oil content of endemic <jats:italic>T. perinicus<\/jats:italic> is reported for the first time. Principal component analysis (PCA) and cluster analysis (CA) were used to investigate the variations in the essential oils of different <jats:italic>Thymus<\/jats:italic> species from Sect. <jats:italic>Hyphodromi<\/jats:italic> (A. Kerner) Hal\u00e1csy.<\/jats:p>","DOI":"10.1002\/cbdv.202100498","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T06:01:07Z","timestamp":1629266467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Essential Oil Composition of Five <i>Thymus S<\/i>pecies from Bulgaria"],"prefix":"10.1002","volume":"18","author":[{"given":"Antoaneta","family":"Trendafilova","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry with Center of Phytochemistry Bulgarian Academy of Sciences  1113 Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milka","family":"Todorova","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry with Center of Phytochemistry Bulgarian Academy of Sciences  1113 Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry with Center of Phytochemistry Bulgarian Academy of Sciences  1113 Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Zhelev","sequence":"additional","affiliation":[{"name":"University of Forestry  1797 Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Aneva","sequence":"additional","affiliation":[{"name":"Institute of Biodiversity and Ecosystem Research Bulgarian Academy of Sciences  1113 Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.04.020"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203216859"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-014-9378-9"},{"key":"e_1_2_7_4_1","first-page":"101","article-title":"\u2018Survey on the distribution, diversity and phyochemistry of genus Thymus in Bulgaria\u2019","volume":"10","author":"Aneva I.","year":"2018","journal-title":"Ecol. Balk."},{"key":"e_1_2_7_5_1","first-page":"85","article-title":"\u2018The essential oil composition of Thymus tosevii and Thymus macedonicus from Bulgaria\u2019","volume":"139","author":"Kulevanova S.","year":"2000","journal-title":"Boll. Chim. Farm."},{"key":"e_1_2_7_6_1","first-page":"27","article-title":"\u2018GC\/MS analiza volatilnih konstituenata Thymus moesiacus Velen\u2019","volume":"2","author":"\u0106avar S.","year":"2009","journal-title":"GHTERS"},{"key":"e_1_2_7_7_1","first-page":"197","article-title":"\u2018Essential oil composition of the Balkan endemic Thymus longedentatus (Degen & Urum.) Ronniger\u2019","volume":"18","author":"Aneva I.","year":"2019","journal-title":"BLACPMA"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01167569"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1997.9700754"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2005.03.008"},{"key":"e_1_2_7_11_1","first-page":"419","article-title":"\u2018Correlation between Chemical Composition of Greek Essential Oils and their Antibacterial Activity against Food-borne Pathogens\u2019","volume":"2","author":"Chorianopoulos N. G.","year":"2007","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1999.9701125"},{"key":"e_1_2_7_13_1","first-page":"40","article-title":"\u2018Chemical analysis and antifungal activity of Thymus striatus\u2019","volume":"18","author":"Couladis M.","year":"2004","journal-title":"Phys. Res."},{"key":"e_1_2_7_14_1","unstructured":"S. \u0106avar D. Vidi\u0107 M.\u2005E. Soli\u0107 M. Maksimovi\u0107 \u2032Comparison of essential oil composition of threeThymus striatusVahl. populations from Balkan Peninsula\u2032 in38th Int. Symp. Essent. Oils Book of Abstracts Graz Austria 2007 p. 224."},{"key":"e_1_2_7_15_1","first-page":"105","article-title":"\u2018Composition and yield of essential oils of various species of the genus Thymus L.\u2019","volume":"39","author":"Karuza-Stojakovi\u0107 L.","year":"1989","journal-title":"Arh. Farm."},{"key":"e_1_2_7_16_1","first-page":"857","article-title":"\u2018Comparative observation on Thymus striatus Vanh and T. striatus var. ophioliticus lacaita in central Italy\u2019","volume":"19","author":"Maleci L. B.","year":"1997","journal-title":"Lagascalia"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2005.10643419"},{"key":"e_1_2_7_18_1","first-page":"119","article-title":"\u2018The essential oils of Thymus balcanus, T. ciliatopubescens and T. pseudo-atticus from Macedonia\u2019","volume":"48","author":"Kulevanova S.","year":"1998","journal-title":"Acta Pharm."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1996.9701028"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2004-1-216"},{"key":"e_1_2_7_21_1","first-page":"61","article-title":"\u2018Essential Oil Composition of Thyme (Thymus zygioides Griseb. var. lycaonicus (Celak.) Ronniger) Wild Growing in Turkey\u2019","volume":"8","author":"Duman E.","year":"2020","journal-title":"Turk. J. Agric. For."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2008.9700053"},{"key":"e_1_2_7_23_1","unstructured":"R.\u2005P. Adams Identification of Essential Oil Components by Gas Chromatography\/Mass Spectroscopy Allured Business Media Carol Stream 2007."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3653552"},{"key":"e_1_2_7_25_1","unstructured":"\u2018NIST Chemistry WebBook\u2019 can be found underhttps:\/\/webbook.nist.gov\/chemistry\/n.d."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/boj.12034"},{"key":"e_1_2_7_27_1","volume-title":"Capillary Gas Chromatography in Essential Oil Analysis","author":"Sandra P.","year":"1987"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202100498","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:53:01Z","timestamp":1693201981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202100498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/cbdv.202100498"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202100498","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2100498"}}