{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:59:20Z","timestamp":1791428360742,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infections caused by parasitic worms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by blood\u2010dwelling of the genus <jats:italic>Schistosoma<\/jats:italic> that affects more than 230\u2005million people worldwide. Since praziquantel has also been extensively used to treat schistosomiasis and other parasitic flatworm infections, there is an urgent need to identify novel anthelmintic compounds, mainly from natural sources. In this study, the hexane extract from roots of <jats:italic>Piper malacophyllum<\/jats:italic> (Piperaceae) showed to be mainly composed for gibbilimbol\u2005B by HPLC\/ESI\u2010HRMS. Based on this result, this compound was isolated by chromatographic steps and its structure was confirmed by NMR. <jats:italic>In\u2005vitro<\/jats:italic> bioassays showed that gibbilimbol\u2005B was more active than praziquantel against larval stage of <jats:italic>S.\u2005mansoni<\/jats:italic>, with effective concentrations of 50\u2009% (EC<jats:sub>50<\/jats:sub>) and 90\u2009% (EC<jats:sub>90<\/jats:sub>) values of 2.6 and 3.4\u2005\u03bcM, respectively. Importantly, gibbilimbol\u2005B showed no cytotoxicity to mammalian cells at a concentration 190\u2005times greater than the antiparasitic effect, giving support for the anthelmintic potential of gibbilimbol\u2005B as lead compound for novel antischistosomal agents.<\/jats:p>","DOI":"10.1002\/cbdv.202100503","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T20:39:36Z","timestamp":1629578376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of Gibbilimbol B, Isolated from <i>Piper malacophyllum<\/i> (Piperaceae), as an Antischistosomal Agent"],"prefix":"10.1002","volume":"18","author":[{"given":"Paulo U.","family":"Carna\u00faba","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas Universidade Guarulhos  Pra\u00e7a Tereza Cristina, 88 Guarulhos SP, 07023-070 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Mengarda","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas Universidade Guarulhos  Pra\u00e7a Tereza Cristina, 88 Guarulhos SP, 07023-070 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas Universidade Guarulhos  Pra\u00e7a Tereza Cristina, 88 Guarulhos SP, 07023-070 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago R.","family":"Morais","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas Universidade Guarulhos  Pra\u00e7a Tereza Cristina, 88 Guarulhos SP, 07023-070 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal de Uberl\u00e2ndia  Av. 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