{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:05:08Z","timestamp":1789495508365,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the following compounds were isolated from the dichloromethane fraction of the stems of <jats:italic>Amomum longiligulare<\/jats:italic> and then characterized: a new benzofuran, namely, longifuran A (<jats:bold>1<\/jats:bold>); five other phenolic compounds, namely, 4\u2010methoxycinnamic acid (<jats:bold>2<\/jats:bold>), 2,5\u2010dimethoxyphenol (<jats:bold>3<\/jats:bold>), eudesmic acid (<jats:bold>4<\/jats:bold>), 1,7\u2010bis(4\u2010hydroxyphenyl)\u20101,4,6\u2010heptatrien\u20103\u2010one (<jats:bold>5<\/jats:bold>), and 4,4\u2019\u2010dihydroxychalcone (<jats:bold>6<\/jats:bold>); and two triterpenoids, namely, 24\u2010methylcycloartan\u20103\u03b2\u2010ol (<jats:bold>7<\/jats:bold>) and 24\u2010methylencycloartan\u20103\u03b2\u2010ol (<jats:bold>8<\/jats:bold>). They were evaluated in terms of their inhibitory effects on NO production in LPS\u2010stimulated RAW 264.7 macrophages. Results indicated that <jats:bold>1<\/jats:bold> and <jats:bold>5<\/jats:bold> exhibited promising inhibitory activities against NO generation with IC<jats:sub>50<\/jats:sub> of 10.47\u00b11.02\u2005\u03bcM and 8.51\u00b11.14\u2005\u03bcM, respectively. Enzymatic assays demonstrated that they remarkably suppressed the secretion of two pro\u2010inflammatory cytokines (i.\u2009e., IL\u20106 and TNF\u2010\u03b1). They also dose\u2010dependently inhibited the expression of inducible nitric oxide synthase and cyclooxygenase\u20102, two important enzymes modulating inflammation. Therefore, <jats:bold>1<\/jats:bold> and <jats:bold>5<\/jats:bold> could be targets for the development of new anti\u2010inflammatory therapeutics<\/jats:p>","DOI":"10.1002\/cbdv.202100518","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T15:53:24Z","timestamp":1635350004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010Inflammatory Properties of Longifuran A, a New Benzofuran from the Stems of <i>Amomum longiligulare<\/i>"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7628-4674","authenticated-orcid":false,"given":"Le","family":"Thanh Huong","sequence":"first","affiliation":[{"name":"University of Science and Technology of Hanoi (USTH) Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham","family":"Anh Thu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of Hanoi (USTH) Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phi","family":"Thi Dao","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doan","family":"Thi Mai Huong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham","family":"Van Cuong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Hai Dang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of Hanoi (USTH) Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-007-0013-x"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453144"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0012-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0066-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S168188"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191087"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1062761"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0960428611000436"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-015-1525-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800672049"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.10.085"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1280338"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100871g"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3184\/030823402103171591"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0602673"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-012-0170-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(93)85548-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2478"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00058-9"},{"key":"e_1_2_7_21_1","first-page":"9143683","article-title":"\u2018Ecological and Phytochemical Studies on Euphorbia retusa (Forssk.) from Egyptian Habitat.\u2019","volume":"2018","author":"Shaaban M.","year":"2018","journal-title":"J. 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