{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:26Z","timestamp":1786977266968,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infections caused by microorganisms are a major cause of morbidity and mortality worldwide, and natural products continue to be important sources for the discovery of new antimicrobial agents. Ursolic acid is a triterpene with known antibacterial action, being naturally found in plants, such as\n                    <jats:italic>Jaracanda oxyphylla<\/jats:italic>\n                    and\n                    <jats:italic>Jacaranda caroba<\/jats:italic>\n                    (Bignoniaceae). Ursolic acid derivative esters have revealed potential biological activities, such as antitumor, antiviral, and antibacterial activity. In this study, sixteen esters (\n                    <jats:bold>1<\/jats:bold>\n                    \u2010\n                    <jats:bold>16<\/jats:bold>\n                    ) were synthesized from ursolic acid using DIC\/DMAP and characterized by infrared (IR), nuclear magnetic resonance (\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010 and\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR) and mass spectrometry. All ursolic acid esters were evaluated against\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    , and the yeast\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . Six compounds are herein described for the first time (\n                    <jats:bold>3<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    ,\n                    <jats:bold>11<\/jats:bold>\n                    ,\n                    <jats:bold>13<\/jats:bold>\n                    ,\n                    <jats:bold>14<\/jats:bold>\n                    and\n                    <jats:bold>16<\/jats:bold>\n                    ) with yields up to 91.6\u2009%. Compounds\n                    <jats:bold>11<\/jats:bold>\n                    (3\n                    <jats:italic>\u03b2\u2010<\/jats:italic>\n                    (3,4\u2010dimethoxybenzoyl)ursolic acid) and\n                    <jats:bold>15<\/jats:bold>\n                    (3\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010nicotinoylursolic acid) displayed promising antifungal activity, with inhibition of\n                    <jats:italic>C.\u2005albicans<\/jats:italic>\n                    growth of 93.1 and 95.9\u2009%, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202100566","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T13:54:55Z","timestamp":1637243695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis and Antimicrobial Activity of Ursolic Acid Ester Derivatives"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-3880","authenticated-orcid":false,"given":"Vinicius Viana","family":"Pereira","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Universidade Federal de Minas Gerais  31270-901 Belo Horizonte-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara R\u00fabia","family":"Pereira","sequence":"additional","affiliation":[{"name":"Chemistry Department Universidade Federal dos Vales do Jequitinhonha e Mucuri  39100-000 Diamantina-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael C\u00e9sar Gon\u00e7alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Chemistry Department Universidade Federal de Minas Gerais  31270-901 Belo Horizonte-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-6625","authenticated-orcid":false,"given":"Lucienir Pains","family":"Duarte","sequence":"additional","affiliation":[{"name":"Chemistry Department Universidade Federal de Minas Gerais  31270-901 Belo Horizonte-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-1609","authenticated-orcid":false,"given":"Jacqueline Aparecida","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Chemistry Department Universidade Federal de Minas Gerais  31270-901 Belo Horizonte-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roqueline Rodrigues","family":"Silva","sequence":"additional","affiliation":[{"name":"Chemistry Department Universidade Federal dos Vales do Jequitinhonha e Mucuri  39100-000 Diamantina-MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.4172\/2153-2435.1000434"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.05.050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00283"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2014.05.047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants6020016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1399380"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.10.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NP00015G"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1344219"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4236\/pp.2012.32018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.083"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19011317"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1499642"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171012197"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1576"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12251"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.5935\/1984-6835.20160073"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800108"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200490109"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126824"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2015.04.021"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903062648"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0028-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000913"},{"key":"e_1_2_7_25_1","first-page":"392","article-title":"\u2018Chemical 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