{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:42Z","timestamp":1786977342328,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic cardiomyopathy is one of the major complications in type\u20052 diabetes associated with myocardial structure abnormality and major cause of morbidity in type\u20052 diabetic patients. Biochanin A is a methylated isoflavone present in flowering tops of\n                    <jats:italic>Trifolium pratense<\/jats:italic>\n                    reported for anti\u2010inflammatory, anti\u2010oxidant, anti\u2010infective, anti\u2010cancer and anti\u2010diabetic activity. The study was designed to assess the efficacy of Biochanin A in type\u20052 diabetic cardiomyopathy. Type\u20052 diabetes was induced in rats feeding high fat diet for two weeks and administration of single low dose of streptozotocin. Biochanin A was administered for 16\u2005weeks orally once in a day (10, 20 and 40\u2005mg\/kg of body weight). Various parameters such as blood glucose, cardiac markers, oxidative stress and hemodynamic parameters, immunohistochemical, histopathological investigation and SIRT1 expression were measured at the end of the study. Biochanin A treatment resulted into reduction in plasma concentration of cardiac markers along with reduction in hyperglycemia, hyperlipidemia and oxidative stress in cardiac tissue. Biochanin A treated animals also demonstrated improvement in hemodynamic parameters. Diabetic animals treated with different doses of Biochanin A shown increased SIRT1 expression in cardiac tissue, and also confirmed reduced cardiac hypertrophy and cardiac protection in histopathological study. Outcome of the study indicates that Biochanin A is the potential candidate to control hyperglycemia, oxidative stress and improve SIRT1 expression in cardiac tissue. Biochanin A might be considered as potential candidate to control progression of cardiomyopathy in type\u20052 diabetes mellitus.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202100591","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T06:34:40Z","timestamp":1643956480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biochanin A Attenuates Cardiomyopathy in Type 2 Diabetic Rats by Increasing SIRT1 Expression and Reducing Oxidative Stress"],"prefix":"10.1002","volume":"19","author":[{"given":"Manisha J.","family":"Oza","sequence":"first","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management, SVKM's NMIMS  V. L. Mehta Road, Vile Parle (W) Mumbai 400056 India"},{"name":"SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W)  Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-7907","authenticated-orcid":false,"given":"Yogesh A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management, SVKM's NMIMS  V. L. Mehta Road, Vile Parle (W) Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018819834869"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12173"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.216"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00793"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1410495"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.11.051"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.073"},{"key":"e_1_2_9_9_1","first-page":"6","article-title":"\u2018Biochanin-A ameliorates experimental diabetic nephropathy by reducing the hyperglycemia induced oxidative stress and renal TGF-\u03b2 expression Biography\u2019","volume":"4","author":"Ahad A.","year":"2013","journal-title":"JDM an open access J. Diabetes"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2016.08.001"},{"key":"e_1_2_9_11_1","unstructured":"J.\u2005I.\u2005R. A V.\u2005V.\u2005S. Uddandrao S. G. S. G. C. P. S. S. T. P. S. P.\u2005P. S. Vadivukkarasi \u2018Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway\u2019 Arch. Physiol. Biochem.2021 1\u20136."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.134882"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0762-4"},{"key":"e_1_2_9_14_1","first-page":"707","article-title":"\u2018Antihyperlipidemic effect of biochanin A on streptozotocin induced diabetic rats.\u2019","volume":"5","author":"Harini R.","year":"2012","journal-title":"J. Pharm. Res."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b00967"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56847-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960200112"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-407821-5.00008-5","volume-title":"Clin. Chem. Immunol. Lab. Qual. Control","author":"Dasgupta A.","year":"2014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/jlpm-20-93"},{"key":"e_1_2_9_20_1","first-page":"14","article-title":"\u2018Effect and mechanisms of zinc supplementation in protecting against diabetic cardiomyopathy in a rat model of type\u20052 diabetes\u2019","volume":"14","author":"Lu Y.","year":"2015","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0443"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4324-2017160741"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NJ01568E"},{"key":"e_1_2_9_24_1","first-page":"1","article-title":"\u2018SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice\u2019","volume":"2017","author":"Ma S.","year":"2017","journal-title":"Oxid. Met."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.01.013"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"H. Luck \u2032Catalase. In: Bergmeyer H.U. Ed. Method of Enzymatic Analysis\u2019 Academic Press New York and London.1965 885\u2013894.","DOI":"10.1016\/B978-0-12-395630-9.50158-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86110-H"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202100591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T22:20:44Z","timestamp":1693088444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202100591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/cbdv.202100591"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202100591","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"assertion":[{"value":"2021-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202100591"}}