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Therefore, once the double bond participated in the polymerization, N\u2010PMI lost its antimicrobial function. N\u2010PMI could achieve azeotropic copolymerization with MMA through reactive extrusion polymerization. N\u2010PMI with a content of 5\u2009% can be evenly inserted into the PMMA chain segment during the copolymerization reaction, thereby increasing the Tg of pure PMMA by up to 15\u2009\u00b0C, which provided the PMMA\u2010co\u2010PMI copolymer with resistance to boiling water sterilization advantageous conditions. In addition, N\u2010PMI with a content of 5\u2009% has little effect on the transparency of PMMA after participating in the copolymerization. Moreover, the trace amount of residual N\u2010PMI made the material have excellent antimicrobial function, and the bacteriostatic zone is extremely small, which provided an excellent guarantee for the safety and durability of the material. As a medical biological material, the PMMA\u2010co\u2010PMI copolymer has a good industrialization application prospects.<\/jats:p>","DOI":"10.1002\/cbdv.202100753","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T09:27:58Z","timestamp":1652434078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibacterial Mechanism of N\u2010PMI and the Characteristics of PMMA\u2010Co\u2010N\u2010PMI Copolymer**"],"prefix":"10.1002","volume":"19","author":[{"given":"Han","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-4785","authenticated-orcid":false,"given":"Yong","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafu","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2007.03.002"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_8_3_1","first-page":"239","article-title":"\u2018Nosocomial Bloodstream Infections in United States Hospitals: A Three-Year Analysis\u2019","author":"Edmond M. 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