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Biotransformation process of the labdane diterpene <jats:italic>ent<\/jats:italic>\u2010labd\u20108(17)\u2010en\u201015,18\u2010dioic acid (<jats:bold>1<\/jats:bold>) carried out with <jats:italic>Cunninghamella elegans<\/jats:italic> afforded five new derivatives (compounds <jats:bold>2<\/jats:bold>\u2013<jats:bold>6<\/jats:bold>). Unusual regioselective hydroxylation of the methyl group at the C\u201020 position of labdane\u2010type diterpene was achieved and all compounds were subjected to cytotoxicity and antifungal evaluations. Compound <jats:bold>1<\/jats:bold> and its derivatives were not cytotoxic to normal (MCF\u201010A) and tumor (MCF\u20107) cell lines. Compounds <jats:bold>2<\/jats:bold> and <jats:bold>3<\/jats:bold> exhibited fungistatic activity against all tested <jats:italic>Candida<\/jats:italic> strains at lower concentrations than fluconazole. Both compounds also showed the strongest fungicidal activity against <jats:italic>C.\u2005albicans<\/jats:italic>, which is the most prevalent fungal agent involved in candidemia.<\/jats:p>","DOI":"10.1002\/cbdv.202100757","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T02:59:15Z","timestamp":1643425155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Production of More Potent Anti\u2010<i>Candida<\/i> Labdane Diterpenes by Biotransformation Using <i>Cunninghamella elegans<\/i>"],"prefix":"10.1002","volume":"19","author":[{"given":"Ingrid P.","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Av. do Caf\u00e9, s\/n 14040-903 Ribeir\u00e3o Preto, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria V.","family":"De Sousa Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Av. do Caf\u00e9, s\/n 14040-903 Ribeir\u00e3o Preto, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolindo A.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Av. do Caf\u00e9, s\/n 14040-903 Ribeir\u00e3o Preto, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Magnetic Resonance Chemistry Department Federal University of S\u00e3o Carlos  S\u00e3o Carlos 13565-905, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren M.","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Av. do Caf\u00e9, s\/n 14040-903 Ribeir\u00e3o Preto, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Nucleus of Research in Sciences and Technology University of Franca  Franca 14404-600, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir Constantino Gomes","family":"Heleno","sequence":"additional","affiliation":[{"name":"Nucleus of Research in Sciences and Technology University of Franca  Franca 14404-600, SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niege A. 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