{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:50:28Z","timestamp":1769503828336,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Astragalus membranaceus<\/jats:italic> is a well\u2010known herb that is widely used in the food and pharmaceutical industries. However, its commercial development has been limited due to wild resource shortages. This study was conducted in 2018 and 2019 to assess the effect of planting density on the major chemical compounds and mineral elements and biomass yield of <jats:italic>A.\u2005membranaceus<\/jats:italic>. The biomass yield (7,700.956\u2005kg) reached the maximum at M2 planting density in 2018. In 2019, astragaloside\u2005IV reached its maximum concentration (0.117\u2009%) at M2 group, which was significantly different from the concentrations obtained at the other groups. Calycosin\u20107\u2010O\u2010\u03b2\u2010D\u2010glucoside (0.062\u2009%) reach its maximum concentration in 2019 at M5, but not significant with M2. The concentration of major chemical compounds among the five groups in 2018 and 2019 all conformed to the Chinese Pharmacopoeia standards. In 2018, the mineral elements (Al, Ba, Fe, Li and Mn) content was higher at M2 than other groups. However, a general decrease in the mineral elements content was observed at M2 group in 2019. Enrichment analysis demonstrated that the enrichment capacity was highest for phosphorus. In conclusion, according to the TOPSIS results, M2 planting density was recommended as the optimal application. For optimal economic benefits, <jats:italic>A.\u2005membranaceus<\/jats:italic> should be harvested when it is 2\u2005years old.<\/jats:p>","DOI":"10.1002\/cbdv.202100778","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T13:10:54Z","timestamp":1639487454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Major Chemical Compounds and Mineral Elements of <i>Astragalus membranaceus<\/i> Cultivated on the Qinghai\u2010Tibet Plateau with Different Planting Densities"],"prefix":"10.1002","volume":"19","author":[{"given":"Lingling","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences  Xining 810008 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucun","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences  Xining 810008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences  Xining 810008 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences  Xining 810008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21030354"},{"key":"e_1_2_9_2_1","first-page":"838","article-title":"\u2018Resource surveys and suitability of origin for genuine medicinal materials, Astragalus membranaceus var mongholicus in Inner Mongolia, Chinese\u2019","volume":"27","author":"Liu D.","year":"2016","journal-title":"J. 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