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Our group showed that the soluble dichloromethane (CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub>) fraction from EtOH extract from <jats:italic>M.\u2005flexuosa<\/jats:italic> stems inhibited the growth of methicillin\u2010susceptible <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) and methicillin\u2010resistant <jats:italic>S.\u2005aureus<\/jats:italic> (MRSA) and it is rich in phenolic compounds. This study aimed to isolate new phenolic compounds from CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> fraction from <jats:italic>M.\u2005flexuosa<\/jats:italic> stems with <jats:italic>in\u2005vitro<\/jats:italic> antibacterial activity. The crude CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> fraction was fractionated by gel permeation chromatography (GPC) followed by semi\u2010preparative RP\u2010HPLC. The antibacterial activity was evaluated using the broth microdilution method against MSSA (ATCC 29213) and MRSA (clinical isolate 155). All compounds were also tested against Gram\u2010negative (<jats:italic>Escherichia coli<\/jats:italic>; ATCC 35218) bacteria and two fungi species (<jats:italic>Candida albicans<\/jats:italic>; ATCC 14053 and <jats:italic>Trichophyton rubrum<\/jats:italic>; ATCC MYA 4438). The chemical structures of isolated compounds were determined by analysis and comparison with literature data of their NMR and HRMS spectra and optical activity. The chemical investigation yielded seven aromatic compounds, of which four, (2<jats:italic>S<\/jats:italic>,15<jats:italic>S<\/jats:italic>)\u20102,15\u2010dimethyl\u20102,15\u2010dioxa\u20101,8(1,4)\u2010dibenzenacyclotetradecaphane (<jats:bold>1<\/jats:bold>), (2<jats:italic>S<\/jats:italic>,5<jats:italic>S<\/jats:italic>)\u20101\u2010(4\u2010hydroxyphenyl)hexane\u20102,5\u2010diol (<jats:bold>3<\/jats:bold>), bruguierol E (<jats:bold>4<\/jats:bold>), and buritin (<jats:bold>5<\/jats:bold>) were previously unreported and three are known compounds identified as 6\u2010(4\u2019\u2010hydroxyphenyl) hexan\u20102\u2010one (<jats:bold>2<\/jats:bold>), (+)\u2010(2<jats:italic>R<\/jats:italic>,3<jats:italic>R<\/jats:italic>)\u2010dihydrokaempferol (<jats:bold>6<\/jats:bold>), and (+)\u2010(2<jats:italic>R<\/jats:italic>)\u2010naringenin (<jats:bold>7<\/jats:bold>). Compounds <jats:bold>1<\/jats:bold> and <jats:bold>7<\/jats:bold> showed antibacterial activity against MRSA and MSSA with minimum inhibitory concentrations (MICs) of between 62.5 and 31.3\u2005\u03bcg\/mL, respectively. Our preliminary findings support that CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> fraction from buriti, a typical species of flooded areas of Brazilian savanna, and its aromatic phenolic compounds are active against MSSA and MRSA contributing with understanding about the traditional use of this species.<\/jats:p>","DOI":"10.1002\/cbdv.202100788","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T06:40:01Z","timestamp":1644561601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Natural Occurring Phenolic Derivatives from <i>Mauritia flexuosa<\/i> (Buriti) Stems and Their Potential Antibacterial Activity against Methicillin\u2010Resistant <i>Staphylococcus aureus<\/i> (MRSA)"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-9853","authenticated-orcid":false,"given":"Djalma Menezes","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Science and Technology State University of Bahia Southwest  Jos\u00e9 Moreira Sobrinho Avenue 45206-191 Jequi\u00e9 Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Batista Carneiro","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Federal University of Tri\u00e2ngulo Mineiro  P\u00e7a Manoel Terra, 330, Abadia 38025-015 Uberaba Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yule Roberta Ferreira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Ecology Laboratory and Plant Propagation Department of General Biology Estadual University of Montes Claros University Campus Prof. Darcy Ribeiro  39401-089 Montes Claros Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia Maria","family":"de Almeida Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry Bioactive Natural Products Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation  Augusto de Lima Avenue, 1715, Barro Preto 30190-002 Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kohlhoff","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry Bioactive Natural Products Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation  Augusto de Lima Avenue, 1715, Barro Preto 30190-002 Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Assun\u00e7\u00e3o","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Federal University of Tri\u00e2ngulo Mineiro  P\u00e7a Manoel Terra, 330, Abadia 38025-015 Uberaba Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-2043","authenticated-orcid":false,"given":"Betania Barros","family":"Cota","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry Bioactive Natural Products Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation  Augusto de Lima Avenue, 1715, Barro Preto 30190-002 Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0044-59672012000100001"},{"key":"e_1_2_10_2_1","first-page":"209","article-title":"\u2018Richness and ethnobotany of palms in kraho indigenous territory, Tocantins, Brazil\u2019","volume":"40","author":"Nascimento A. 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