{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:03:02Z","timestamp":1757451782038,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002467","name":"Dankook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evodileptin B (<jats:bold>1<\/jats:bold>) is a natural anthranilate derivative isolated from the ethanol extract of the aerial parts of <jats:italic>Evodia lepta<\/jats:italic> (Spreng.) Merr., a traditional medicinal plant of the family Rutaceae. We readily synthesized <jats:bold>1<\/jats:bold> via the amidation of phloretic with methyl anthranilate and evaluate its neuroprotective activity using a <jats:italic>C.\u2005elegans<\/jats:italic> Parkinson's disease (PD) model. The results showed that evodilpetin B ameliorated MPP<jats:sup>+<\/jats:sup>\u2010induced dopaminergic (DA) neurodegeneration in a dose\u2010dependent manner. Evodileptin B treatment also significantly improved the DA neurotransmission\u2010related behavioral defects such as reduced locomotory and food\u2010sensing ability of worms under MPP<jats:sup>+<\/jats:sup> exposure conditions, suggesting its potential application for the functional restoration of DA neurons. In addition, we found that <jats:bold>1<\/jats:bold> has an ability to regulate aggregation of \u03b1\u2010synuclein by increasing proteasome activity in the human \u03b1\u2010synuclein\u2010expressing mutant worms. These results demonstrate that evodileptin B has strong neuroprotective properties and may be useful in the treatment of PD.<\/jats:p>","DOI":"10.1002\/cbdv.202100808","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T03:13:57Z","timestamp":1647832437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of Evodileptin B, a Natural Anthranilate Derivative Isolated from <i>Evodia lepta<\/i>, and Evaluation of Its Therapeutic Potential against Parkinson's Disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Soobin","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy Dankook University  119 Dandae-ro, Dongnam-gu Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Woosuk University  443 Samnye-ro, Wanju-gun Jeonbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Seok","family":"Cha","sequence":"additional","affiliation":[{"name":"College of Pharmacy Woosuk University  443 Samnye-ro, Wanju-gun Jeonbuk Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-1181","authenticated-orcid":false,"given":"Young Taek","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dankook University  119 Dandae-ro, Dongnam-gu Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.11.009"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.01.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"R. Nass D.\u2005H. Hall D.\u2005M. 3rd\u2005Miller R.\u2005D. Blakely \u2018Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans\u2019 Proc. Natl. Acad. Sci. U.S.A.2002 99 3264\u20133269.","DOI":"10.1073\/pnas.042497999"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00006-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.05.030"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.12.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2019.1670169"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21842"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.02.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3002108"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90301-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2014.920235"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3406"},{"key":"e_1_2_7_14_1","first-page":"767230","article-title":"\u2018Mitochondrial fusion\/fission, transport and autophagy in Parkinson's disease: when mitochondria get nasty\u2019","volume":"2011","author":"Ardu\u00edno D. M.","year":"2011","journal-title":"Parkinsons Dis."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.08.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.545749"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202100808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202100808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:03:41Z","timestamp":1692651821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202100808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/cbdv.202100808"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202100808","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"type":"print","value":"1612-1872"},{"type":"electronic","value":"1612-1880"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"2021-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202100808"}}