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No vaccine or drug is available against ZIKV. We herein report the anti\u2010ZIKV activity of 36 plant extracts containing polyphenols and\/or triterpenes. ZIKV\u2010infected Vero CCL\u201081 cells were treated with samples at non\u2010cytotoxic concentrations, determined by MTT and LDH assays. One third of the extracts elicited concentration\u2010dependent anti\u2010ZIKV effect, with viral loads reduction from 0.4 to 3.8\u2005log units. The 12 active extracts were tested on ZIKV\u2010infected SH\u2010SY5Y cells and significant reductions of viral loads (in log units) were induced by <jats:italic>Maytenus ilicifolia<\/jats:italic> (4.5\u2005log), <jats:italic>Terminalia phaeocarpa<\/jats:italic> (3.7\u2005log), <jats:italic>Maytenus rigida<\/jats:italic> (1.7\u2005log) and <jats:italic>Echinodorus grandiflorus<\/jats:italic> (1.7\u2005log) extracts. Median cytotoxic concentration (CC<jats:sub>50<\/jats:sub>) of these extracts in Vero cells were higher than in SH\u2010SY5Y lineage. <jats:italic>M. ilicifolia<\/jats:italic> (IC<jats:sub>50<\/jats:sub>=16.8\u00b110.3\u2005\u03bcg\/mL, SI=3.4) and <jats:italic>T. phaeocarpa<\/jats:italic> (IC<jats:sub>50<\/jats:sub>=22.0\u00b16.8\u2005\u03bcg\/mL, SI=4.8) were the most active extracts. UPLC\u2010ESI\u2010MS\/MS analysis of <jats:italic>M. ilicifolia<\/jats:italic> extract led to the identification of 7 triterpenes, of which lupeol and a mixture of friedelin\/friedelinol showed no activity against ZIKV. The composition of <jats:italic>T. phaeocarpa<\/jats:italic> extract comprises phenolic acids, ellagitannins and flavonoids, as recently reported by us. In conclusion, the anti\u2010ZIKV activity of 12 plant extracts is here described for the first time and polyphenols and triterpenes were identified as the probable bioactive constituents of <jats:italic>T. phaeocarpa<\/jats:italic> and <jats:italic>M. ilicifolia<\/jats:italic>, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202100842","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T06:34:13Z","timestamp":1647239653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010Zika Virus Activity of Plant Extracts Containing Polyphenols and Triterpenes on Vero CCL\u201081 and Human Neuroblastoma SH\u2010SY5Y Cells"],"prefix":"10.1002","volume":"19","author":[{"given":"Ros\u00e2ngela","family":"Santos Pereira","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Products Faculty of Pharmacy Universidade Federal de Minas Gerais  Av. Ant\u00f4nio Carlos, 6627, Pampulha CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Vasconcelos Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"},{"name":"Department of Morphology Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Luiz Menezes Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products Faculty of Pharmacy Universidade Federal de Minas Gerais  Av. Ant\u00f4nio Carlos, 6627, Pampulha CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Rodrigues Valadares Campana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products Faculty of Pharmacy Universidade Federal de Minas Gerais  Av. Ant\u00f4nio Carlos, 6627, Pampulha CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Maia de P\u00e1dua","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products Faculty of Pharmacy Universidade Federal de Minas Gerais  Av. Ant\u00f4nio Carlos, 6627, Pampulha CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Genetics Ecology and Evolution Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Oki","sequence":"additional","affiliation":[{"name":"Department of Genetics Ecology and Evolution Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Heiden","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria Clima Temperado  CEP 96010-971 Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo Wilson","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Genetics Ecology and Evolution Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djalma","family":"Menezes de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universidade Estadual do Sudoeste da Bahia  CEP 45208-091 Jequi\u00e9, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele G.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Microbiology Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Martins Teixeira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences Universidade Federal de Minas Gerais  CEP 31270-901 Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern\u00e3o","family":"Castro Braga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products Faculty of Pharmacy Universidade Federal de Minas Gerais  Av. 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