{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T01:33:08Z","timestamp":1787275988235,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The discovery of new antimicrobial molecules is crucial for combating drug\u2010resistant bacterial and fungal infections that pose a dangerous threat to human health. In the current research, we applied a molecular hybridization approach to synthesize original thiosemicarbazide\u2010triazole derivatives starting from (<jats:italic>S<\/jats:italic>)\u2010naproxen (<jats:bold>7a<\/jats:bold>\u2013<jats:bold>7k<\/jats:bold>). After structural characterization using FT\u2010IR, <jats:sup>1<\/jats:sup>H\u2010NMR, <jats:sup>13<\/jats:sup>C\u2010NMR, and HR\u2010MS, the obtained compounds were screened for their antimicrobial activities against <jats:italic>Staphylococcus aureus<\/jats:italic> ATCC 29213, <jats:italic>Escherichia coli<\/jats:italic> ATCC 25922, <jats:italic>Candida albicans<\/jats:italic> ATCC 10231 and their isolates, as well. Although all compounds were found to be moderate antimicrobial agents, in general, their antibacterial activities were better than antifungal effects. Among the tested compounds, <jats:bold>7j<\/jats:bold> carrying nitrophenyl group on the thiosemicarbazide functionality represented the best MIC value against <jats:italic>S.\u2005aureus<\/jats:italic> isolate. Finally, molecular docking studies were performed in the active pocket of <jats:italic>S.\u2005aureus<\/jats:italic> flavohemoglobin to rationalize the obtained biological data.<\/jats:p>","DOI":"10.1002\/cbdv.202100900","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T15:09:39Z","timestamp":1645542579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of New Thiosemicarbazide\u2010Triazole Hybrid Derivatives of (<i>S<\/i>)\u2010Naproxen"],"prefix":"10.1002","volume":"19","author":[{"given":"M. \u0130hsan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Erciyes University  Kayseri 38039 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy Erciyes University  Kayseri 38039 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyase G\u00f6zde","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Hacettepe University  Ankara 06100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e. G\u00fcniz","family":"K\u00fc\u00e7\u00fckg\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Fenerbah\u00e7e University  Istanbul 34758 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_2_10_1_1","first-page":"1","article-title":"\u2018Infectious disease in an era of global change\u2019","author":"Baker R. E.","year":"2021","journal-title":"Nat. Rev. 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