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To estimate their effects of the products on toxicity in zebrafish embryos and juvenile fishes, the two precursors and three target products were assayed involving in hatching rate, survival rate, morphology, heart rate, and apoptosis of cardiomyocytes. The results showed that the target products enhanced the hatching and survival rate of zebrafish embryos, decreased the malformation rate and the apoptosis of cardiomyocytes. It should be suggested that the one\u2010step synthesis route with high yield makes the industrial application of the target products possible due to significantly reduced toxicity. The two new by\u2010products provide potential candidates for the applications of pharmaceutical industry in the future.<\/jats:p>","DOI":"10.1002\/cbdv.202100928","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T03:08:51Z","timestamp":1646363331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New 18<i>\u03b2<\/i>\u2010Glycyrrhetinic Acid\u2010Emodin Esters Synthetized by a One\u2010Step Innovative Route, Its Structural Characterization, and <i>in Vivo<\/i> Toxicity Assessed on Zebrafish Models"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-9563","authenticated-orcid":false,"given":"Yuan","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Changchun University of Chinese Medicine  Changchun 130117 Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Changchun University of Chinese Medicine  Changchun 130117 Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Changchun University of Chinese Medicine  Changchun 130117 Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghua","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Vocational and Technical Education Yunnan Normal University  Kunming 650021 Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-8489","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Changchun University of Chinese Medicine  Changchun 130117 Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1779"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0493008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967126"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104598"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf101841r"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.02.025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(97)00013-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.07.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.03.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.115"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00484"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22060924"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0987"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1723-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2640-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.05.028"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.02.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.02.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01077-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.10.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957399"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12885"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22928"},{"key":"e_1_2_8_24_1","unstructured":"T.\u2005F. 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