{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:58:06Z","timestamp":1790387886768,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ketene dithioacetal <jats:bold>3<\/jats:bold> generated from 2\u2010nitroperchlorobutadiene <jats:bold>1<\/jats:bold> reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene\u2010<jats:italic>N<\/jats:italic>,<jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>\u2010acetals and <jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>\u2010acetals <jats:bold>4a<\/jats:bold>\u2013<jats:bold>f<\/jats:bold>, <jats:bold>5a<\/jats:bold>\u2013<jats:bold>h<\/jats:bold> as heterocyclic dithiolanes. They were separated\/purified by chromatographic methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives <jats:bold>4e<\/jats:bold> and <jats:bold>5h<\/jats:bold>, which have MIC=15.6\u2005\u03bcg\/mL for the test culture of <jats:italic>Mycobacterium luteum<\/jats:italic> bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future molecular design to enhance the antimicrobial action. Ketene dithioacetals <jats:bold>3<\/jats:bold>, <jats:bold>4a<\/jats:bold>, <jats:bold>4b<\/jats:bold>, <jats:bold>4e<\/jats:bold>, <jats:bold>5g<\/jats:bold> (50\u2005mg\/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole\u2010induced convulsions after single oral administration both at 3\u2005h and 24\u2005h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals.<\/jats:p>","DOI":"10.1002\/cbdv.202100931","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T12:51:20Z","timestamp":1654692680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New Ketene Dithioacetals Generated from 2\u2010Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities"],"prefix":"10.1002","volume":"19","author":[{"given":"Serdar Goksin","family":"Aydinli","sequence":"first","affiliation":[{"name":"Istanbul University-Cerrahpasa Engineering Faculty Department of Chemistry  Division of Organic Chemistry 34320 Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Bulut","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Engineering Faculty Department of Chemistry  Division of Organic Chemistry 34320 Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-7274","authenticated-orcid":false,"given":"Nahide Gulsah","family":"Deniz","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Engineering Faculty Department of Chemistry  Division of Organic Chemistry 34320 Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Sayil","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Engineering Faculty Department of Chemistry  Division of Organic Chemistry 34320 Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Komarovska\u2010Porokhnyavets","sequence":"additional","affiliation":[{"name":"Lviv Polytechnic National University Department of Technology of Biologically Active Substances Pharmacy and Biotechnology  79013 Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vira","family":"Lubenets","sequence":"additional","affiliation":[{"name":"Lviv Polytechnic National University Department of Technology of Biologically Active Substances Pharmacy and Biotechnology  79013 Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Zvarych","sequence":"additional","affiliation":[{"name":"Lviv Polytechnic National University Department of Technology of Biologically Active Substances Pharmacy and Biotechnology  79013 Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Stasevych","sequence":"additional","affiliation":[{"name":"Lviv Polytechnic National University Department of Technology of Biologically Active Substances Pharmacy and Biotechnology  79013 Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia","family":"Nesterkina","sequence":"additional","affiliation":[{"name":"Odessa International Medical University Department of Pharmacology and Pharmacy  65000 Odessa Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Kravchenko","sequence":"additional","affiliation":[{"name":"Odessa International Medical University Department of Pharmacology and Pharmacy  65000 Odessa Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-4998(200001)56:1<3::AID-PS107>3.0.CO;2-P"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11020054"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122863"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1070\/RC1997v066n10ABEH000310"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2020.152297"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-04-10020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3998\/ark.5550190.0008.109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.10.170"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/znb-2010-0710"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2019.151363"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2011.01.128"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2020.1799010"},{"key":"e_1_2_10_13_1","first-page":"1360","article-title":"\u2018Regioselective Substitution of Vinyl Halide by n-Alkyl Mercaptans and Subsequent Reactions with Versatile Cyclic Secondary Amines\u2019","volume":"22","author":"Ibis C.","year":"2010","journal-title":"Asian J. 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