{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:30Z","timestamp":1753862850663,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schistosomiasis, a tropical disease caused by flatworms, may affect the liver, spleen, bladder, and intestine. <jats:italic>Casearia sylvestris<\/jats:italic> Swartz, a medicinal plant, displays antiprotozoal, antimicrobial, antifungal, and antiulcer activities. We have evaluated the <jats:italic>in\u2005vitro<\/jats:italic> schistosomicidal activity of two <jats:italic>C. sylvestris<\/jats:italic> varieties against <jats:italic>Schistosoma mansoni<\/jats:italic> adult worms at concentrations between 12.5 and 200 \u03bcg\/mL. At 100 and 200 \u03bcg\/mL, the ethanolic <jats:italic>C. sylvestris<\/jats:italic> var. <jats:italic>sylvestris<\/jats:italic> leaf extract enriched in casearin\u2010like diterpenes eliminated 100\u2009% of the parasites after incubation for 72 h and 48 h, respectively, whilst the same extract at 200 \u03bcg\/mL eliminated 96\u2009%, 100\u2009%, and 100\u2009% of the parasites after incubation for 24, 48, and 72 h, respectively. On the other hand, the hydroalcoholic <jats:italic>C. sylvestris<\/jats:italic> var. <jats:italic>lingua<\/jats:italic> leaf extract at 200 \u03bcg\/mL eliminated 60.4 and 66.7\u2009% of the parasites after incubation for 48 and 72 h, respectively. The presence of casearin\u2010like diterpenes and glycosylated flavonoids was confirmed based on chromatographic techniques and mass spectrometry data.<\/jats:p>","DOI":"10.1002\/cbdv.202100948","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T20:19:24Z","timestamp":1639081164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In Vitro<\/i> Schistosomicidal Activities of the Leaf Extracts from <i>Casearia sylvestris<\/i> Varieties"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-909X","authenticated-orcid":false,"given":"Fl\u00e1vio A.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Department of Drugs and Medicines S\u00e3o Paulo State University (Unesp) School of Pharmaceutical Sciences  Araraquara-Ja\u00fa Road, Km 01, s\/n, 14.801-903 Araraquara SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno C.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology University of Franca  Franca S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7217-0840","authenticated-orcid":false,"given":"Fernando B.","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines S\u00e3o Paulo State University (Unesp) School of Pharmaceutical Sciences  Araraquara-Ja\u00fa Road, Km 01, s\/n, 14.801-903 Araraquara SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio C. P.","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines S\u00e3o Paulo State University (Unesp) School of Pharmaceutical Sciences  Araraquara-Ja\u00fa Road, Km 01, s\/n, 14.801-903 Araraquara SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-147X","authenticated-orcid":false,"given":"Eduardo J.","family":"Crevelin","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of S\u00e3o Paulo (USP) Faculty of Philosophy  Sciences and Letters, Av. do Caf\u00e9, s\/n, 14.040-903 Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-1729","authenticated-orcid":false,"given":"Ant\u00f4nio E. M.","family":"Crotti","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of S\u00e3o Paulo (USP) Faculty of Philosophy  Sciences and Letters, Av. do Caf\u00e9, s\/n, 14.040-903 Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-6752","authenticated-orcid":false,"given":"Lizandra G. 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