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For the analysis of diuretic effect, the female rats received the treatment with MEGHL (3, 10, and 30\u2005mg\/kg), DCM (1, 3 and 10\u2005mg\/kg), EtA (1, 3, and 10\u2005mg\/kg), hydrochlorothiazide (HCTZ; 10\u2005mg\/kg), or vehicle (VEH) after an overload of saline solution. At the end 8\u2005h of the experiment, the urinary parameters were measured. Additionally, the antiurolithic effect was analyzed, in which sodium oxalate was added in synthetic urine in the presence or absence of MEGHL, DCM, and EtA in different concentrations (0.1, 0.3, and 1\u2005mg\/mL). MEGHL, DCM, and EtA were able to promote 8\u2010h diuresis in rats. MEGHL treatment at dose 30\u2005mg\/kg was accompanied by increased urinary Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup> excretion. Moreover, the DCM and EtA fractions treatment increased K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup> excretion in the urine, although it does not cause any change in Na<jats:sup>+<\/jats:sup> elimination. All the preparations were able to exert an antiurolithic effect <jats:italic>in\u2005vitro<\/jats:italic>, decreasing the number of calcium oxalate crystals of the monohydrate and dihydrate types. Taking together, the results presented herein showed that the preparations of <jats:italic>G.\u2005humilis<\/jats:italic> leaves are promising strategies to induce diuresis and antiurolithic effects.<\/jats:p>","DOI":"10.1002\/cbdv.202200022","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T14:24:49Z","timestamp":1661264689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diuretic and Antiurolithic Effect of <i>Garcinia humilis<\/i> (Vahl) C.D. Adams Leaves, a Medicinal Plant Native to South American Countries"],"prefix":"10.1002","volume":"19","author":[{"given":"Lu\u00edsa Nath\u00e1lia Bolda","family":"Mariano","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane Aline","family":"Pontioli","sequence":"additional","affiliation":[{"name":"Curso de Nutri\u00e7\u00e3o Escola de Ci\u00eancias da Sa\u00fade Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Aline","family":"da Silva","sequence":"additional","affiliation":[{"name":"Curso de Nutri\u00e7\u00e3o Escola de Ci\u00eancias da Sa\u00fade Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"Cechinel\u2010Filho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  Rua Uruguai, 458, Centro 88302-901 Itaja\u00ed Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_6_1_1","first-page":"99","article-title":"\u2018Race, ethnicity and urolithiasis: A critical review\u2019","volume":"41","author":"Rodgers A. 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