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Extract <jats:italic>in\u2005vitro<\/jats:italic> exhibited notable total antioxidant activity (FRAP value=1.0 \u03bcmol Fe<jats:sup>2+<\/jats:sup>\/mg), and scavenging of DPPH (<jats:italic>SC<\/jats:italic><jats:sub>50<\/jats:sub>=62.5\u2005\u03bcg\/ml) and <jats:sup>\u2022<\/jats:sup>OH radicals (49.5\u2009% at 20\u2005\u03bcg\/ml in 2\u2010deoxyribose assay). <jats:italic>In vitro<\/jats:italic> on isolated rat ileum, extract exhibited significant spasmolytic activity, <jats:italic>i.\u2009e<\/jats:italic>., it showed 124.6\u2009% of maximal atropine effect on spontaneous contractions (at 100\u2005\u03bcg\/ml), and reduced spasmogenic effect of KCl (80\u2005m<jats:sc>m<\/jats:sc>) to 44.4\u2009% (at 60\u2005\u03bcg\/ml) and of highest applied concentration of ACh to 26.3\u2009% (at 120\u2005\u03bcg\/ml). In parallel experiments, spasmolytic effect of CGA was also demonstrated. In acute EtOH\u2010induced gastric ulceration model in rats, extract (100\u2005mg\/kg <jats:italic>p.o<\/jats:italic>.) showed significant gastroprotective effect (gastric damage score 0.50), similar to ranitidine (20\u2005mg\/kg <jats:italic>p.o<\/jats:italic>.). Obtained results showed that tested <jats:italic>F. heuffelii<\/jats:italic> polar extract represents new herbal preparation with potential use against some gastrointestinal complaints.<\/jats:p>","DOI":"10.1002\/cbdv.202200047","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T19:24:31Z","timestamp":1647977071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of <i>Ferula heuffelii<\/i> Underground Parts"],"prefix":"10.1002","volume":"19","author":[{"given":"Ivan","family":"Pavlovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade-Faculty of Pharmacy  Vojvode Stepe 450 11221 Belgrade Serbia"},{"name":"Roche d.o.o.  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