{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:46:17Z","timestamp":1770702377930,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclophosphamide (CTX) is one of the most commonly used alkylating agents for the treatment of various cancers; however, CTX\u2010induced nephrotoxicity is one of the most prevailing side effects of the drug. <jats:italic>Shorea roxburghii<\/jats:italic> is a plant with diverse bioactivities including antioxidant, anti\u2010inflammatory and renoprotective effects. This study investigated the nephroprotective effect of <jats:italic>Shorea roxburghii<\/jats:italic> phenolic extract (SRPF) against CTX\u2010induced nephrotoxicity in rats. The rats were treated with SRPF (100 and 400\u2005mg\/kg) for 5 weeks and were concomitantly administered with CTX. The results indicated that treatment with SRPF significantly decreased serum creatinine, blood urea nitrogen (BUN), uric acid as well as renal MDA, IL\u20106, TNF\u2010\u03b1, IL\u20101\u03b2, NF\u2010kB and caspase\u20103 levels. Furthermore, SRPF augmented the activities of renal SOD, CAT, GSH and GPx. SRPF also improved renal histopathological damages caused by CTX administration. In conclusion, these results suggested that SRPF showed substantial protective effects against CTX\u2010mediated renal toxicity via its antioxidant and anti\u2010inflammatory effects.<\/jats:p>","DOI":"10.1002\/cbdv.202200053","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:03:34Z","timestamp":1648616614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective Effects of <i>Shorea roxburghii<\/i> Phenolic Extract on Nephrotoxicity Induced by Cyclophosphamide: Impact on Oxidative Stress, Biochemical and Histopathological Alterations"],"prefix":"10.1002","volume":"19","author":[{"given":"Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Blood Purification Center Wannan Medical College Affiliated Yijishan Hospital  Wuhu 241001 Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjun","family":"Tong","sequence":"additional","affiliation":[{"name":"Blood Purification Center Wannan Medical College Affiliated Yijishan Hospital  Wuhu 241001 Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Blood Purification Center Wannan Medical College Affiliated Yijishan Hospital  Wuhu 241001 Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Blood Purification Center Wannan Medical College Affiliated Yijishan Hospital  Wuhu 241001 Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6800-4919","authenticated-orcid":false,"given":"Opeyemi Joshua","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Traditional Thai Medical Research and Innovation Center, Faculty of Traditional Thai Medicine Prince of Songkla University  Hat Yai 90110 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112255"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.146"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13083"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.112"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1250-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-020-01064-w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118630"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.09.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117901"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.01.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020451"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100415"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900661"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23043"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2018.64.12.3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S260731"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9100925"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0138"},{"key":"e_1_2_9_20_1","first-page":"1","article-title":"\u2018Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity\u2019","volume":"94","author":"Said E.","year":"2015","journal-title":"Can. 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