{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:20:30Z","timestamp":1768476030025,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study focused on the biological evaluation and chemical characterization of <jats:italic>Malabaila lasiocarpa<\/jats:italic> Boiss. (<jats:italic>M. lasiocarpa<\/jats:italic>) (Family: Apiaceae). The phytochemical profile, antioxidant, enzyme inhibitory of the methanolic, aqueous, dichloromethane, hexane extracts were investigated. Based on UHPLC\u2010HRMS analyses, a total of 101 peaks were annotated or identified for the first time in <jats:italic>M. lasiocarpa<\/jats:italic> extracts. They include hydroxybenzoic, hydroxycinnamic, acylquinic acids and their glycosides, <jats:italic>C<\/jats:italic>\u2010 and <jats:italic>O<\/jats:italic>\u2010glycosyl and O\u2010diglycosyl flavonoids. In addition, 10 simple mono\u2010 and disubstituted coumarins together with 10 furanocoumarins were tentatively annotated. The methanolic extract possessing the highest phenolic (24.36\u00b10.60\u2005mg gallic acid equivalent\/g extract) and flavonoid (69.15\u00b10.37\u2005mg rutin equivalent\/g extract) content also exhibited the strongest radical scavenging potential against 2,2\u2010diphenyl\u20101 picrylhydrazyl (21.73\u00b10.42\u2005mg Trolox equivalent\/g extract, respectively), and highest reducing capacity (57.81\u00b10.97 and 28.00\u00b10.40\u2005mg Trolox equivalent\/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively). The dichloromethane extract substantially depressed the tyrosinase (73.92\u00b15.37\u2005mg kojic acid equivalent\/g extract), \u03b1\u2010amylase (0.63\u00b10.01\u2005mmol acarbose equivalent\/g extract) and \u03b1\u2010glucosidase (0.69\u00b10.02\u2005mmol acarbose equivalent\/g extract) enzymes. This study has produced critical scientific data on <jats:italic>M. lasiocarpa<\/jats:italic> which are potential contenders for the development of novel phyto\u2010pharmaceuticals.<\/jats:p>","DOI":"10.1002\/cbdv.202200068","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T16:05:51Z","timestamp":1646841951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detailed Chemical Characterization and Biological Propensities of <i>Malabaila lasiocarpa<\/i> Extracts: An Endemic Plant to Turkey"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"first","affiliation":[{"name":"Physiology and Biochemistry Research Laboratory Department of Biology Science Faculty Selcuk University  Campus Konya 42130 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrina","family":"Zheleva\u2010Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Medical University-Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru Y\u00fcce","family":"Babacan","sequence":"additional","affiliation":[{"name":"Munzur University Pertek Sakine Gen\u00e7 Vocational School  Tunceli Pertek 62500 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0131dvan","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Landscape Architecture, Faculty of Agriculture Bingol University  12000 Bing\u00f6l Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"\u00c7ak\u0131lc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Munzur University Pertek Sakine Gen\u00e7 Vocational School  Tunceli Pertek 62500 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabeelah Bibi","family":"Sadeer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences University of Mauritius  R\u00e9duit 80837 Mauritius"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanoel V.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Amazonas (UFAM)  Manaus 69080-900, AM Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences University of Mauritius  R\u00e9duit 80837 Mauritius"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Naviglio","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Naples Federico II  via Cintia, 4 80126 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology University of Naples Federico II  via Pansini 5 80131 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Montesano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Naples Federico II  Via D. Montesano 49 80131 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Centro Tecnol\u00f3gico de la Carne de Galicia  Avd. Galicia No. 4, Parque Tecnol\u00f3gico de Galicia, San Cibrao das Vi\u00f1as 32900 Ourense Spain"},{"name":"Universidade de Vigo, \u00c1rea de Tecnolox\u00eda dos Alimentos, Facultade de Ciencias  32004 Ourense Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reneta","family":"Gevrenova","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Medical University-Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.95849"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30138-w"},{"key":"e_1_2_7_3_1","unstructured":"B. Allkin \u2032Useful plants \u2013 medicines: at least 28 187 plant species are currently recorded as being of medicinal use\u2032 In: Willis K.\u2005J. (Ed.) State of the World's Plants 2017. 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