{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:58:38Z","timestamp":1773269918654,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations in lipid and lipoprotein metabolism are factors that trigger several negative metabolic complications. Hyperlipidemia is the starting point for the development of comorbidities of the cardiovascular system, such as atherosclerosis. The search for compounds that reduce high levels of total cholesterol and triglycerides has been widely reported in several publications in the literature. Phthalimide derivatives have been extensively researched with various biological actions. In this study we evaluated the antihyperlipidemic ability of three phthalimide derivatives (FGT\u20102, FGT\u20103 and FGT\u20104) on a model of obesity and insulin resistance in mice. The animals were submitted to a hyperlipid diet for 60\u2005days. On the thirtieth day they were treated with phthalimides (20\u2005mg\/kg). The positive control group was treated with Simvastatin (20\u2005mg\/kg) and the negative control received only the carboxymethylcellulose vehicle. Biochemical and histological analyzes of all groups were analyzed. The animals treated with phthalimidic derivatives had a reduction in total cholesterol, low density and very low density lipoproteins (LDL\u2010c and VLDL\u2010c), triglycerides and fasting glycemia when compared to the negative control group. The treated animals also showed good results when analyzing the atherogenic indexes Castelli i and II and the ratio Triglycerides\/HDL\u2010c. In the oral glucose tolerance test and in the insulin tolerance test, animals treated with phthalimides were more sensitive to the action of the hormone regulating carbohydrate uptake. In the evaluation of the transaminases (AST\/ALT), the animals of the group treated with phthalimides presented a lower elevation than the other groups of the experiment, the same observed with the uric acid evaluation. Histological analyzes were performed on liver, kidney, heart and pancreas samples. The groups treated with the compounds FGT\u20102 and FGT3 presented discrete alterations in the liver and kidney. FGT\u20104 did not present histological alterations for both tissues and the three phthalimide derivatives did not cause alterations in the other organs. These results suggest that the phthalimides tested can act as antihyperlipidemic agents and have a pleiotropic action, by acting also reducing glycemia in insulin resistance model mimicking diabetes mellitus type\u20052. These compounds may appear as a new approach in the treatment of obesity and complications, which are multifaceted.<\/jats:p>","DOI":"10.1002\/cbdv.202200119","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T14:48:27Z","timestamp":1662994107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antihyperlipidemic Activity of Glycoconjugated Phthalimides in Mice Submitted to a Model of Dyslipidemia and Insulin Resistance"],"prefix":"10.1002","volume":"19","author":[{"given":"Jos\u00e9 Guedes","family":"da Silva J\u00fanior","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Lip\u00eddeos e Biomol\u00e9culas e suas Aplica\u00e7\u00f5es em Doen\u00e7as Prevalentes e Negligenciadas (LAB-DPN) Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco (UFPE)  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-1655","authenticated-orcid":false,"given":"Hallysson Douglas Andrade","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Lip\u00eddeos e Biomol\u00e9culas e suas Aplica\u00e7\u00f5es em Doen\u00e7as Prevalentes e Negligenciadas (LAB-DPN) Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco (UFPE)  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael Gomes","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Citol\u00f3gicas e Moleculares (LPCM), UFPE, Departamento de Histologia e Embriologia, Centro de Bioci\u00eancias Universidade Federal de Pernambuco (UFPE)  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinto Costa","family":"da Silva Neto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Citol\u00f3gicas e Moleculares (LPCM), UFPE, Departamento de Histologia e Embriologia, Centro de Bioci\u00eancias Universidade Federal de Pernambuco (UFPE)  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronaldo Nascimento","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Compostos Bioativos (LSCB) Departamento de Qu\u00edmica Universidade Federal Rural de Pernambuco  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalom P\u00f4rto","family":"de Oliveira Assis","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biotecnologia e Ci\u00eancias Ambientais (NPCIAMB) Departamento de Medicina Universidade Cat\u00f3lica de Pernambuco, UNICAP  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia","family":"de Menezes Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Lip\u00eddeos e Biomol\u00e9culas e suas Aplica\u00e7\u00f5es em Doen\u00e7as Prevalentes e Negligenciadas (LAB-DPN) Departamento de Bioqu\u00edmica Centro de Bioci\u00eancias Universidade Federal de Pernambuco (UFPE)  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.09.071"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00134-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.12.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/2327-6924.12510"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.04.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.suppl_1.S1"},{"key":"e_1_2_8_7_1","first-page":"295","article-title":"\u2018An\u00e1lise comparativa do perfil lip\u00eddico de homens do Estado de Pernambuco em rela\u00e7\u00e3o \u00e0s diretrizes brasileiras sobre dislipidemias\u2019","volume":"41","author":"Santos B. S.","year":"2009","journal-title":"Rev. Bras. Anal. Clin."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2538"},{"key":"e_1_2_8_9_1","first-page":"275","article-title":"\u2018Dislipidemias na inf\u00e2ncia e na adolesc\u00eancia\u2019","volume":"29","author":"Giuliano I. C. B.","year":"2008","journal-title":"Rev. Paul. Pediatr."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.570746"},{"key":"e_1_2_8_11_1","first-page":"e46","article-title":"\u2018Heart disease and stroke statistics \u2013 2010 update: a report from the American Heart Association\u2019","volume":"121","author":"Lloyd-Jones D.","year":"2000","journal-title":"Circulation"},{"key":"e_1_2_8_12_1","first-page":"182","article-title":"\u2018Hepatoprotective, antihyperlipidemic, and anti-inflammatory activity of Moringa oleifera in diabetic-induced damage in male wistar rats\u2019","volume":"9","author":"Omodanisi I. E.","year":"2017","journal-title":"Pharm. Res."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.266274"},{"key":"e_1_2_8_14_1","first-page":"1","article-title":"\u2018Role of statin therapy in primary prevention of cardiovascular disease in elderly patients\u2019","volume":"28","author":"Strandberg T. E.","year":"2019","journal-title":"Curr. Atheroscler. Rep."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570179417666200325124712"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800388"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/925925"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(01)00088-X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.07.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00356a022"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.02.033"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcme.2016.05.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.13016FP"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61965-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2610"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(14)70002-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.235"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61190-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530314666141128115225"},{"key":"e_1_2_8_31_1","first-page":"241","article-title":"\u2018AMPK activation: a therapeutic target for type 2 diabetes?\u2019","volume":"7","author":"Coughlan K. A.","year":"2014","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302006000200007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27157"},{"key":"e_1_2_8_34_1","first-page":"117","article-title":"\u2018The de ritis ratio: the test of time\u2019","volume":"34","author":"Botros M.","year":"2013","journal-title":"Clin. Biochem. Rev."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09508"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835d951e"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt320"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i4.509"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23122"},{"key":"e_1_2_8_40_1","first-page":"98","article-title":"\u2018Nephrological aspects of surgical weight correction in morbid obesity\u2019","volume":"6","author":"Bobkova I. N.","year":"2018","journal-title":"Ter. Arkh."},{"key":"e_1_2_8_41_1","first-page":"65","article-title":"\u2018Obesity and kidney disease\u2019","volume":"39","author":"Bezerra G. S. J.","year":"2017","journal-title":"J. Bras. Nefrol."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0085-3"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202200119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:53:30Z","timestamp":1692687210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202200119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cbdv.202200119"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202200119","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]},"assertion":[{"value":"2022-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200119"}}