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Pancreatic lipase has been considered a key enzyme for the treatment of obesity. Herein, we reported the synthesis and enzyme inhibitions of a series of sulfonates as possible tyrosinase and pancreatic lipase inhibitors. According to the calculated IC<jats:sub>50<\/jats:sub>values, compound<jats:bold>3f<\/jats:bold>(74.1\u00b111.1\u2005\u03bcM) and compound<jats:bold>3c<\/jats:bold>(86.6\u00b16.9\u2005\u03bcM) were determined to be the best inhibitors among the synthesized compounds for the tyrosinase and pancreatic lipase enzymes, respectively. The approach yielded at extremely high level by creating very flexible structural domains for the chemically modified groups. The structural characterization of the target molecules was implemented by<jats:sup>1<\/jats:sup>H\u2010NMR,<jats:sup>13<\/jats:sup>C\u2010NMR, and HR\u2010MS analyses. Also, molecular docking studies of the synthesized compounds with tyrosinase and pancreatic lipase enzymes were conducted using AutoDock Vina software. Additionally, the studies of the absorption distribution, metabolism, and excretion (ADME) were performed to uncover the target compounds\u2032 pharmacokinetics, drug similarities, and medicinal properties of the novel sulfonate derivatives bearing salicylaldehyde.<\/jats:p>","DOI":"10.1002\/cbdv.202200140","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T17:54:57Z","timestamp":1652464497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Synthesis, Biological Activity and Molecular Docking Studies of Novel Sulfonate Derivatives Bearing Salicylaldehyde"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-5794","authenticated-orcid":false,"given":"Adem","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Mu\u015f Alparslan University Mu\u015f 49250 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Bursal","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Mu\u015f Alparslan University Mu\u015f 49250 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2020.151660"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500324g"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4018042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4000769"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA03588H"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-021-02739-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104305"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA00724K"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.55.3.164"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116344"},{"key":"e_1_2_10_11_1","first-page":"2249","article-title":"\u2018Analysis of Alkyl, Aryl Sulphonate Ester \u2013 Genotoxic Impurities (GIS) In Active Pharmaceutical Ingredient(API's) and drug product\u2019","volume":"10","author":"Firke S. 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