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The current pattern of management of diabetes included synthetic or plant based oral hypoglycemic drugs and insulin but drug resentence is become a very big issues in antidiabetic therapy. Thus, it's very earnest to discover now medication for this disease. Now the days, it is well acknowledged that diabetic patients are more prone towards covid and related complications. Thus, medical practitioners reformed the methodology of prescribing medication for covid infected antidiabetic therapy and encouraging the medication contains dual pharmacological properties. It is also well know that polyphenols specifically hold a significant role in oxidative stress and reduced the severity of many inflammatory diseases. <jats:italic>Cucumis melo<\/jats:italic> has rich history as ethano\u2010pharmacological use in Indian subcontinent. The fruit and seed are well\u2010known for the treatment of various diseases due to the presence of phenolics. Therefore, in this study, the combined mixture of flower and seeds were used for the extraction of polyphenolic rich extract and tested for antidiabetic activity through the antioxidant and <jats:italic>in\u2005vivo<\/jats:italic> experiments. The antioxidant potential measurement exhibited that the selected plant extract has the significant competence to down\u2010regulate oxidative stress (DPPH scavenging IC<jats:sub>50<\/jats:sub> at 60.7\u00b11.05\u2005\u03bcg\/mL, ABTS IC<jats:sub>50<\/jats:sub> at 62.15\u00b10.50\u2005\u03bcg\/mL). Furthermore, the major polyphenolic phyto\u2010compounds derived from the <jats:italic>Cucumis melo<\/jats:italic> were used for <jats:italic>in\u2005silico<\/jats:italic> anticovid activity, docking, and complementarity studies. The anticovid activity prognosis reflected that selected phyto\u2010compounds amentoflavone and vanillic acid have optimal possibility to interact with 3C\u2010like protease and through this moderate anticovid activity can be exhibit. The docking experiments established that the selected compounds have propensity to interact with protein tyrosine phosphatase 1B, 11\u03b2\u2010Hydroxysteroid dehydrogenase, superoxide dismutase, glutathione peroxidase, and catalase \u03b2\u2010glucuronidase receptor. <jats:italic>In\u2005vivo<\/jats:italic> experiments showed that 500\u2005mg\/kg, <jats:italic>Cucumis melo<\/jats:italic> extract ominously amplified body weight, plasma insulin, high\u2010density lipoprotein levels, and biochemical markers. Furthermore, extract significantly downregulate the blood glucose, total cholesterol, triglycerides, low\u2010density lipoprotein, and very low\u2010density lipoprotein.<\/jats:p>","DOI":"10.1002\/cbdv.202200200","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T07:34:22Z","timestamp":1660203262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Cucumis melo<\/i> var. <i>momordica<\/i> as a Potent Antidiabetic, Antioxidant and Possible Anticovid Alternative: Investigation through Experimental and Computational Methods"],"prefix":"10.1002","volume":"19","author":[{"given":"Jagat Pal","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Pharmacology United Institute of Pharmacy, Industrial area  Naini Prayagraj 211010 India"},{"name":"Department of Pharmacology Kamla Nehru Institute of Management and Technology  Sultanpur 228118 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grishina","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Modeling of Drugs Higher Medical and Biological School South Ural State University  Chelyabinsk 454008 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Shahbaaz","sequence":"additional","affiliation":[{"name":"South African Medical Research Council Bioinformatics Unit South African National Bioinformatics Institute University of the Western Cape  Private Bag X17 Bellville, Cape Town 7535 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Mukerjee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology United Institute of Pharmacy, Industrial area  Naini Prayagraj 211010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology United Institute of Pharmacy, Industrial area  Naini Prayagraj 211010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-9755","authenticated-orcid":false,"given":"Prateek","family":"Pathak","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Modeling of Drugs Higher Medical and Biological School South Ural State University  Chelyabinsk 454008 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061337"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399813666170505120621"},{"key":"e_1_2_9_3_1","first-page":"I5003","article-title":"\u2018Trends in incidence of total or type 2 diabetes: systematic review\u2019","volume":"11","author":"Magliano D. 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