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The resulting complex was characterized using FTIR, UV\/VIS, CHNS, TGA, ICP\u2010MS, and Mass spectroscopy techniques. The in\u2010vitro cytotoxicity was studied on the MDA\u2010MB\u2010231 as a cancerous cell line and the HUVEC as a normal cell line. Reactive oxygen species (ROS) production was measured using the 2\u2032,7\u2032\u2010dichlorofluorescein diacetate (DCFDA) test in the MDA\u2010MB\u2010231 cancer cell lines. The in\u2010vitro assays revealed that all synthesized copper complexes exhibited a higher cytotoxicity effect than carboplatin as a positive control on the MDA\u2010MB\u2010231 cells. While the synthesized complexes exhibited cytotoxic effects on cancerous cell lines, they are practically safe on normal cells. The Cu\u2010Cur\u2010BPYD complexes (<jats:bold>a5<\/jats:bold> &amp; <jats:bold>b5<\/jats:bold>) exhibited higher cytotoxicity on MDA\u2010MB\u2010231 cells with IC<jats:sub>50<\/jats:sub>s around 4.9 and 2.3\u2005mM, respectively. It can be concluded that the synthesized Cu\u2010Cur\u2010BPYD complexes (<jats:bold>a5<\/jats:bold> &amp; <jats:bold>b5<\/jats:bold>) could be considered effective anticancer candidates in complementary studies.<\/jats:p>","DOI":"10.1002\/cbdv.202200202","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T02:05:58Z","timestamp":1664244358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Copper\u2010Curcumin\u2010Bipyridine Dicarboxylate Complexes as Anticancer Candidates"],"prefix":"10.1002","volume":"19","author":[{"given":"Fatemeh","family":"Emami","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Aliomrani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Isfahan Pharmaceutical Sciences Research Center School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Tangestaninejad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Catalysis Division University of Isfahan  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Northern Analytical Lab Services University of Northern British Columbia  Prince George BC Canada"},{"name":"Department of Chemistry Faculty of Science and Engineering University of Northern British Columbia 3333 University Way  Prince George BC V2\u2005N 4Z9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadmahdi","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-821X","authenticated-orcid":false,"given":"Mahboubeh","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31891-8"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.03.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0111-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S119488"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400135x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.06.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00284"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051033"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137094"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.03.026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC00524J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT01040E"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA00425G"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2013.04.029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00088B"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"V.\u2005T. 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