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This study aimed to assess the larvicidal activity of cinnamic ester derivates against <jats:italic>Aedes aegypti<\/jats:italic> larvae, along with evaluating their toxicity effect to assess its safety as a larvicide. Ethyl cinnamate demonstrated larvicidal activity (LC<jats:sub>50<\/jats:sub>=48.59\u2005\u03bcg\/mL). Morphological changes in larvae were detected, as a degenerative response in the thorax. Through molecular docking, the molecular binding mode between <jats:bold>3b<\/jats:bold>, <jats:bold>3c<\/jats:bold>, and acetylcholinesterase showed strong hydrogen bond interactions. Preliminary <jats:italic>in\u2005vitro<\/jats:italic> cell viability revealed the non\u2010cytotoxicity of <jats:bold>3c<\/jats:bold>. Ecotoxicity results indicated a sensitivity of <jats:italic>Artemia salina<\/jats:italic> to cinnamic esters. The phytotoxicity bioassays show potential for cinnamic compounds to enhance germination and root development. These findings suggest that compound <jats:bold>3c<\/jats:bold> is more suitable as a larvicide since it demonstrated low toxicity.<\/jats:p>","DOI":"10.1002\/cbdv.202200256","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T19:04:27Z","timestamp":1664478267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis of Esters Containing Cinnamoyl Motif with Potential Larvicide Action: A Computational, Ecotoxicity and <i>in Vitro<\/i> Cytotoxicity Assessments"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-2370","authenticated-orcid":false,"given":"Paulo Ricardo","family":"dos Santos Correia","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-1626","authenticated-orcid":false,"given":"Cenira Monteiro","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-2197","authenticated-orcid":false,"given":"Cristhyan Rychard","family":"da Silva Cunha","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-2183","authenticated-orcid":false,"given":"Rafael Antonio Santos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-0291","authenticated-orcid":false,"given":"Monaly","family":"de Oliveira Lima","sequence":"additional","affiliation":[{"name":"Institute of Biological and Heath Science Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-0598","authenticated-orcid":false,"given":"Saraliny Bezerra","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-5075","authenticated-orcid":false,"given":"Emiliano","family":"de Oliveira Barreto","sequence":"additional","affiliation":[{"name":"Institute of Biological and Heath Science Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-9564","authenticated-orcid":false,"given":"Josealdo","family":"Tonholo","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-4546","authenticated-orcid":false,"given":"Dimas Jos\u00e9","family":"da Paz Lima","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology Federal University of Alagoas  Avenida Lourival de Melo Mota 57070-970 Maceio, AL Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"Pan American Health Organization \u2018Technical document for the implementation of interventions based on generic operational scenarios forAedes aegypticontrol 2016."},{"key":"e_1_2_9_2_1","first-page":"118","article-title":"\u2018Dengue, Chikungunya E Zika V\u00edrus No Brasil: Situa\u00e7\u00e3o Epidemiol\u00f3gica, Aspectos Cl\u00ednicos E Medidas Preventivas\u2019","volume":"3","author":"Maniero V. 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