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This method yielded 1\u2010(4\u2010trifluoromethoxybenzyl)\u20103\u2010alkylbenzimidazolium bromide salts. These benzimidazolium salts were characterized by using<jats:sup>1<\/jats:sup>H\u2010NMR,<jats:sup>13<\/jats:sup>C\u2010NMR, FT\u2010IR spectroscopy, and elemental analysis techniques. The crystal structure of<jats:bold>1f<\/jats:bold>was enlightened by single crystal X\u2010ray diffraction studies. Also, the enzyme inhibition effects of the synthesised compounds were investigated. They demonstrated highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (K<jats:sub>i<\/jats:sub>values are in the range of 7.24\u00b10.99 to 39.12\u00b15.66\u2005nM, 5.57\u00b10.96 to 43.07\u00b111.76\u2005nM, and 4.38\u00b10.43 to 18.68\u00b13.60\u2005nM for AChE, hCA I, and hCA II, respectively). In molecular docking study, the interactions of active compounds showing activity against AChE and hCAs enzymes were examined. The most active compound<jats:bold>1f<\/jats:bold>has \u221210.90\u2005kcal\/mol binding energy value against AChE enzyme, and the potential structure compound<jats:bold>1e<\/jats:bold>, which has activity against hCA I and hCA II enzymes, was \u22127.51 and \u22128.93\u2005kcal\/mol, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202200257","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T20:08:19Z","timestamp":1666210099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Benzimidazolium Salts Containing Trifluoromethoxybenzyl: Synthesis, Characterization, Crystal Structure, Molecular Docking Studies and Enzymes Inhibitory Properties"],"prefix":"10.1002","volume":"19","author":[{"given":"Mahmut","family":"Hamide","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Arts and Science Cukurova University 01330- Adana 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