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The structures of sulfonamide derivatives were characterized by spectroscopic and X\u2010ray diffraction methods. All compounds were screened for acetylcholinesterase (AChE) inhibitory studies and 2,2\u2010diphenyl\u20101\u2010picrylhydrazil (DPPH) radical scavenging activities. Among the compounds tested, compound<jats:bold>M1<\/jats:bold>showed the best activity against both AChE (IC<jats:sub>50<\/jats:sub>=42.09\u2005\u03bcg\/mL for AChE) and DPPH (IC<jats:sub>50<\/jats:sub>=9.94\u2005\u03bcg\/mL for DPPH). By placing compounds at the active site of AChE, their binding energies and modes were determined. Docking studies were performed in order to investigate binding interaction between the synthesized compounds and AChE. The most active<jats:bold>M1<\/jats:bold>compound showed its low CDOCKER energy (\u221265,834\u2005kcal\/mol).<\/jats:p>","DOI":"10.1002\/cbdv.202200325","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T15:23:45Z","timestamp":1660922625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis, Biological Evaluation and Docking Study of Mono\u2010 and Di\u2010Sulfonamide Derivatives as Antioxidant Agents and Acetylcholinesterase Inhibitors"],"prefix":"10.1002","volume":"19","author":[{"given":"Seyit Ali","family":"G\u00fcng\u00f6r","sequence":"first","affiliation":[{"name":"Chemistry Department Kahramanmaras S\u00fctc\u00fc Imam University 46100 Kahramanmaras Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130rfan","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Chemistry Department Kahramanmaras S\u00fctc\u00fc Imam University 46100 Kahramanmaras Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zge","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Chemistry Department Kahramanmaras S\u00fctc\u00fc Imam University 46100 Kahramanmaras Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugba Taskin","family":"Tok","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gaziantep University 27310 Gaziantep Turkey"},{"name":"Department of Bioinformatics and Computational Biology Gaziantep University Institute of Health Sciences 27310 Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Chemistry Department Kahramanmaras S\u00fctc\u00fc Imam University 46100 Kahramanmaras Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1583606"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.12.042"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1351540"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00426"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.036"},{"key":"e_1_2_7_7_1","article-title":"\u2018New acetylcholinesterase inhibitors for Alzheimer's disease\u2019","volume":"2012","author":"Mehta M.","year":"2012","journal-title":"Int. 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