{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:37Z","timestamp":1753862797878,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: It has been reported that intestinal ischemia\u2010reperfusion injury (IIRI) is closely related to inflammatory response, apoptosis and oxidative stress. Ellagic acid (EA) has been proved to have antioxidant and anti\u2010inflammatory effects and can inhibit tumor angiogenesis. The purpose of this study was to investigate the protective effects of EA on IIRI in mice. <jats:bold>Methods<\/jats:bold>: A mouse model of IIRI was established by clamping the mesenteric artery. Effects and mechanisms of EA on IIRI were investigate by transcriptomics combined with functional experiments. <jats:bold>Results<\/jats:bold>: The symptoms of IIRI were reflected in significant increases in inflammatory factors such as TNF\u2010\u03b1 and IL\u20101\u03b2; significant increases in oxidative stress indicators such as MDA and GSH and decreases in SOD and promotion of the apoptotic protein Bax\/Bcl\u20102. These indicators were significantly alleviated by EA. And after EA treatment, transcriptomics results identified AKT1 differentially expressed mRNAs mainly enriched in PI3K\/AKT signalling pathway. <jats:bold>Conclusion<\/jats:bold>: This study illustrates the protective effects against IIRI, the possible mechanisms were also studied. This study provides new scientific information for the application of EA in IIRI therapy.<\/jats:p>","DOI":"10.1002\/cbdv.202200345","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T15:02:01Z","timestamp":1665414121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ellagic Acid Alleviates Mice Intestinal Ischemia\u2010Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments"],"prefix":"10.1002","volume":"19","author":[{"given":"Shuyuan","family":"Fan","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Liaoning Normal University  Dalian 116029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Liaoning Normal University  Dalian 116029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Liaoning Normal University  Dalian 116029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Diao","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dalian Medical University  Dalian 116044 China"},{"name":"Dalian Anti-Infective Traditional Chinese Medicine Development Engineering Technology Research Center  Dalian 116044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00112.2013"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.04.063"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15787"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13146"},{"key":"e_1_2_8_5_1","first-page":"63","article-title":"\u2018Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4\/NF-kappaB pathway activation\u2019","author":"Du L.","year":"2019","journal-title":"Food Nutr. 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