{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:50:50Z","timestamp":1768481450136,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573694"],"award-info":[{"award-number":["81573694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used UV\u2010guided method to isolate and identify 12 secondary metabolites from <jats:italic>Meehania fargesii<\/jats:italic> var. Radicans for the first time, including eight triterpenoids (<jats:bold>1<\/jats:bold>\u2013<jats:bold>8<\/jats:bold>), two phenylpropanoid derivatives (<jats:bold>9<\/jats:bold>\u2013<jats:bold>10<\/jats:bold>) and two flavone glycosides (<jats:bold>11<\/jats:bold>\u2013<jats:bold>12<\/jats:bold>). Their structures were identified by NMR spectroscopic methods, as well as literature comparison. The identified compounds and positive drugs (amoxicillin, omeprazole and clarithromycin) were further analyzed for their <jats:italic>in silico<\/jats:italic> docking interactions with HtrA using igemdock. Docking studies revealed the high binding affinity of phytochemicals at significant sites with HtrA, compounds <jats:bold>11<\/jats:bold> and <jats:bold>12<\/jats:bold> exhibiting stronger binding ability than standard drug, <jats:bold>1<\/jats:bold> and <jats:bold>3<\/jats:bold>\u2013<jats:bold>10<\/jats:bold> demonstrating comparable docking capacity to standard drugs. The chemotaxonomic relationships were carried out to exploring the possibilities of other medicinal plants against Hp\u2010induced gastric carcinoma. The results demonstrated there are closely chemotaxonomic similarity among several genera of the Lamiaceae family as well as among Lamiaceae, Actinidiaceae and Rosaceae families, indicating a similar chemical compositions and anti\u2010Hp\u2010induces gastric carcinoma activity among them.<\/jats:p>","DOI":"10.1002\/cbdv.202200383","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T04:04:30Z","timestamp":1656043470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insight into the Potential of <i>Meehania fargesii<\/i> var. Radicans against Hp\u2010Induced Gastric Carcinoma Based on Phytochemical and Molecular Docking Studies"],"prefix":"10.1002","volume":"19","author":[{"given":"GuangXin","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Song","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XuePeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaMing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-4916","authenticated-orcid":false,"given":"DaLi","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.154"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117171"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.59.88"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-010-0501-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700454"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np1007922"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153060"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"\u2018Chemical constituents from the leaves of psidium guajava linn. and their chemotaxonomic significance\u2019","volume":"14","author":"Zhou G. X.","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"\u2018Chemical constituents of the aerial parts of Salvia judaica Boiss. from Jordan\u2019","volume":"34","author":"Al-Qudah M. A.","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202001030"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113668"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927022.2021.1880576"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00697"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1413556"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01121"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_8_19_1","first-page":"358","article-title":"\u2018Triterpenes from aerial parts of Clematoclethra scandens subsp. actinidioides.\u2019","volume":"38","author":"Xiao S. J.","year":"2013","journal-title":"Chin. J. Chem."},{"key":"e_1_2_8_20_1","first-page":"978","article-title":"\u2018Chemical study on Saurauia nepaulensis.\u2019","volume":"19","author":"Xiao Y. H.","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"e_1_2_8_21_1","first-page":"121","article-title":"\u2018Triterpenoids from Saurauia napaulensis (Saurauiaceae)\u2019","volume":"30","author":"Wang Q.","year":"2008","journal-title":"Acta Bot. Yunnan."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202200383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:13:25Z","timestamp":1692814405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202200383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/cbdv.202200383"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202200383","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200383"}}