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Non\u2010alcoholic steatohepatitis (NASH) is a deteriorating form of NAFLD, which can eventually develop into fibrosis, cirrhosis, and liver cancer. The reason for NAFLD\/NASH development is complicated, such as liver lipid metabolism, oxidative stress, inflammatory response, apoptosis and autophagy, liver fibrosis and gut microbiota. Apart from bariatric surgery and lifestyle changes, officially approved drug therapy for NAFLD\/NASH treatment is lacking. Salidroside (SDS) is a phenolic compound extensively distributed in the tubers of <jats:italic>Rhodiola<\/jats:italic> plants, which possesses many significant biological activities. This review summarized the related targets regulated by SDS in treating NAFLD\/NASH. It is indicated that SDS could improve the status of NAFLD\/NASH by ameliorating abnormal lipid metabolism, inhibiting oxidative stress, regulating apoptosis and autophagy, reducing inflammatory response, alleviating fibrosis and regulating gut microbiota. In conclusion, although the multiple bioactivities of SDS have been confirmed, the clinical data are inadequate and need to become the focus of attention in the later study.<\/jats:p>","DOI":"10.1002\/cbdv.202200401","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T02:03:43Z","timestamp":1665367423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Salidroside in the Treatment of NAFLD\/NASH"],"prefix":"10.1002","volume":"19","author":[{"given":"Baozhen","family":"Qu","sequence":"first","affiliation":[{"name":"Qingdao Cancer Prevention and Treatment Research Institute Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  127 Siliunan Road Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemao","family":"Liu","sequence":"additional","affiliation":[{"name":"Qingdao Cancer Prevention and Treatment Research Institute Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  127 Siliunan Road Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oncology Center Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology Center Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao Cancer Prevention and Treatment Research Institute Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  127 Siliunan Road Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-4887","authenticated-orcid":false,"given":"Linlin","family":"Lu","sequence":"additional","affiliation":[{"name":"Qingdao Cancer Prevention and Treatment Research Institute Qingdao Central Hospital The Second Affiliated Hospital of Medical College of Qingdao University  127 Siliunan Road Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23838"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_19"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10809"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092062"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2018.09.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26672"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.06.023"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00254"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2015.04.007"},{"key":"e_1_2_10_16_1","first-page":"57","article-title":"\u2018[Hepatoprotective properties of liquid extract of Rhodiola rosea]\u2019","volume":"65","author":"Iaremii I. 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