{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:23:15Z","timestamp":1776680595683,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Inula racemosa<\/jats:italic>, a resourceful critically endangered medicinal herb in the Himalayas is traditionally utilized to cure various human disorders. The species is a wealthy source of sesquiterpene lactones has many pharmacological properties. To quantify and identify the best genetic stocks for a maximum build\u2010up of desired metabolites (isoalantolactone and alantolactone) among existent cytotypes in the species, LC\u2010MS\/MS analysis was made. The other comprehensive experiments carried out at present included detailed meiotic examinations of different populations collected from different areas of Kashmir Himalayas. The results presented the occurrence of variable chromosome numbers as<jats:italic>n<\/jats:italic>=10 and<jats:italic>n<\/jats:italic>=20 in different populations, but the tetraploid cytotype (<jats:italic>n<\/jats:italic>=20) is new for the species. The LC\u2010MS\/MS investigation revealed significant variability in the content of sesquiterpene lactones in different plant tissues (stem, leaf, and root). An upsurge in the quantity of isoalantolactone and alantolactone was noticed with increasing ploidy levels along the increasing altitudes. Therefore, a habit to accumulate abundant quantities of secondary metabolites and increased adaptability by species\/cytotypes thriving at higher altitudes is seen among tetraploid cytotypes during the present investigation. Also, the chromosomal variations seem to enhance the flexibility of polyploid species primarily at upper elevations. Thus, the present study strongly provides quantification of elite cytotypes\/chemotypes with optimum concentration of secondary metabolites.<\/jats:p>","DOI":"10.1002\/cbdv.202200486","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T11:43:33Z","timestamp":1666266213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phytochemical Diversity in Relation to Cytogenetic Variability in<i>Inula racemosa<\/i>Hook.f., an Endangered Medicinal Plant of Himalayas"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-8619","authenticated-orcid":false,"given":"Syed","family":"Mudassir Jeelani","sequence":"first","affiliation":[{"name":"Plant Biotechnology Division CSIR- Indian Institute of Integrative Medicine Canal Road Jammu 180001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-0044","authenticated-orcid":false,"given":"Mohd.","family":"Shahnawaz","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Division CSIR- Indian Institute of Integrative Medicine Canal Road Jammu 180001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajai","family":"Prakash Gupta","sequence":"additional","affiliation":[{"name":"Quality Control and Quality Assurance Division CSIR- Indian Institute of Integrative Medicine Canal Road Jammu 180001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surrinder K.","family":"Lattoo","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Division CSIR- Indian Institute of Integrative Medicine Canal Road Jammu 180001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2012.06.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.008"},{"key":"e_1_2_10_5_1","first-page":"157","volume-title":"Role and regulation of plants phenolics in abiotic stress tolerance","author":"Naikoo M. I.","year":"2019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040762"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.06.044"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.09.015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1423298"},{"key":"e_1_2_10_10_1","first-page":"16369","article-title":"\u2018A review on the micropropogation of an important medicinal plant Inula racemosa Hook. F.\u2019","volume":"7","author":"Sharma P.","year":"2017","journal-title":"Indian J. Dent. Res."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.868882"},{"key":"e_1_2_10_12_1","first-page":"62","article-title":"\u2018Comparative study of Inula racemosa and Saussurea lappa on the glucose level in Albino rats\u2019","volume":"15","author":"Chaturvedi P.","year":"1995","journal-title":"Anc. sci. life"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.09.001"},{"key":"e_1_2_10_14_1","first-page":"101","article-title":"\u2018Role of Lipistat in protection against isoproterenol induced myocardial necrosis in rats: a biochemical and histopathological study\u2019","volume":"42","author":"Seth S. D.","year":"1998","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"248532","DOI":"10.1155\/2013\/248532","article-title":"\u2018Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone\u2019","author":"Rasul A.","year":"2013","journal-title":"Sci. World J."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2010.06.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.126657"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/768359"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.053"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12039-012-0347-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2014.977575"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4429"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-020-02989-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1946090"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10709-006-7668-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-012-0413-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00606-013-0871-1"},{"key":"e_1_2_10_28_1","unstructured":"D.\u2005C. Zlesak Ed. D.\u2005C. Zlesak \u2018Pollen diameter and guard cell length as predictor of ploidy in diverse rose cultivars species and breeding lines. In: Zlesak D.\u2005C. (ed) Roses. Floriculture and ornamental biotechnology vol 3 (special issue 1). Global Science Books Ltd UK 2009 pp. 53\u201370."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122-006-0414-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.03.043"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00411-8"},{"key":"e_1_2_10_32_1","first-page":"909","article-title":"\u2018Determination of Emodin, Chrysophanol, and Physcion by HPLC in the Chinese Medicine Rumex japonicus Houtt\u2019","volume":"31","author":"Lin C.","year":"2012","journal-title":"Lat. Am. J. Pharm."},{"key":"e_1_2_10_33_1","first-page":"83","article-title":"\u2018Phytochemical investigation of Rumex luminiastrum\u2019","volume":"64","author":"Abd El-Fattah H.","year":"1994","journal-title":"Acta Pharm. Hung."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007262831715"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1072-6"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2013.06.017"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2012.10.003"},{"key":"e_1_2_10_38_1","first-page":"175","article-title":"\u2018Effect of temperature on growth and stevioside formation of Stevia rebaudiana Bertoni\u2019","volume":"37","author":"Mizukami H.","year":"1983","journal-title":"Shoyakugaku Zasshi"},{"key":"e_1_2_10_39_1","first-page":"67","article-title":"\u2018Stress-protective role of secondary metabolites: diversity of functions and mechanisms\u2019","volume":"34","author":"Edreva A.","year":"2008","journal-title":"Gen. Appl. Plant Physiol."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2820-z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2012.05006.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2014.07.012"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/err373"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.1733"},{"key":"e_1_2_10_45_1","first-page":"831","article-title":"\u2018Effects of altitude on anatomy and concentration of crocin, picrocrocin and safranal in Crocus sativus L.\u2019","volume":"5","author":"Zarinkamar F.","year":"2011","journal-title":"Aust. J. Crop Sci."},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837828"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15074526"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113966"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202200486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202200486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T07:11:16Z","timestamp":1728198676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202200486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/cbdv.202200486"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202200486","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200486"}}