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The chemical structures of the synthesized compounds were characterized by <jats:sup>1<\/jats:sup>H\u2010NMR, <jats:sup>13<\/jats:sup>C\u2010NMR, and HRMS spectra. The inhibitory potential of the compounds was evaluated on COXs by <jats:italic>in\u2005vitro<\/jats:italic> and <jats:italic>in silico<\/jats:italic> studies. The COX2 inhibitory activity of the most potent inhibitor MEST1 (IC<jats:sub>50<\/jats:sub>: 0.048\u2005\u03bcM) was found to be much higher than the COX2 inhibitory activity of aspirin (IC<jats:sub>50<\/jats:sub>: 2.60\u2005\u03bcM). In docking studies, the strongest inhibitor among the compounds synthesized was predicted to be MEST1, with the lowest binding energy. Docking studies revealed that MEST1 extends from the hydrophobic channel to the top of the cyclooxygenase active site, forming various interactions with residues in the binding pocket.<\/jats:p>","DOI":"10.1002\/cbdv.202200509","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T08:25:32Z","timestamp":1671006332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis of New Ester Derivatives of Salicylic Acid and Evaluation of Their COX Inhibitory Potential"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-5925","authenticated-orcid":false,"given":"Mehmet","family":"Koca","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bar\u0131\u015f","family":"An\u0131l","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Ni\u015fanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Bay\u0131r","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Ercan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emrah","family":"\u00d6zakar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Faculty of Pharmacy Atat\u00fcrk University  Erzurum 25240 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2010.04.010"},{"key":"e_1_2_9_2_1","first-page":"620","article-title":"\u2018Sur la composition de la salicine et quelques-unes de ses r\u00e9actions\u2019","volume":"6","author":"Piria R.","year":"1838","journal-title":"C.\u2005R. 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