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Herein, we evaluated if the hydroalcoholic extract of rabbiteye blueberry (<jats:italic>Vaccinium ashei<\/jats:italic> Reade) leaves (HEV) promotes an antidepressant\u2010like effect in rodents using chronic experimental approaches. The effect of repeated administration of HEV (50\u2005mg\/kg, p.o.) on the immobility time was assessed in the forced swimming test (FST) in an unpredictable chronic mild stress (UCMS) model. Repeated treatment with HEV reversed the depressive\u2010like behavior induced by UCMS by reducing the immobility time. Besides, the exposure to HEV caused no changes in relative organ weights in rats submitted to UCMS. The results indicated that HEV administration presented antidepressant\u2010like action devoid of toxic effects. Thus, it is possible to suggest its potential as a safe and accessible therapeutic tool in the management of depression and other related mood disorders.<\/jats:p>","DOI":"10.1002\/cbdv.202200514","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T20:24:08Z","timestamp":1670963048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hydroalcoholic Extract of Rabbiteye Blueberry (<i>Vaccinium ashei<\/i>) Leaves Mitigates Unpredictable Chronic Mild Stress Model Inducing Depressive\u2010Like Behavior in Rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Verciane","family":"Schneider Cezarotto","sequence":"first","affiliation":[{"name":"Departamento de Farm\u00e1cia Industrial Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal de Santa Maria  Santa Maria RS 97105-900 Brazil"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade 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