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Therefore, its methanolic extract was divided into hexane (CA\u2212H), chloroform (CA\u2212C), ethyl acetate (CA\u2212E) and butanol (CA\u2212B) soluble fractions. CA\u2212H and CA\u2212C were found rich in phenolics (30.73\u00b10.63 and 20.15\u00b10.59\u2005mg GAE\/g of the extract, respectively), and the same fractions exhibited significant antioxidant activities (DPPH: 5.23\u00b10.11 &amp; 12.34\u00b10.17\u2005mg TE\/g extract, respectively; ABTS: 36.82\u00b10.04 &amp; 56.74\u00b10.61\u2005mg TE\/g extract, respectively). Also in CUPRAC activity assay, CA\u2212H and CA\u2212C exhibited highest activities as 87.30\u00b10.46 and 56.74\u00b10.61\u2005mg TE\/g extract, respectively, while CA\u2212C was most active in FRAP activity assay with value of 40.21\u00b12.19\u2005mg TE\/g extract. Total antioxidant capacity (1.23\u00b10.033\u2005mmol TE\/g extract) was also found higher for CA\u2212C, while CA\u2212H activity was also comparable, however, CA\u2212H showed higher metal chelating activity (22.74\u00b10.001\u2005mg EDTAE\/g extract) than that of CA\u2212C (17.55\u00b10.22\u2005mg EDTAE\/g extract). These activities clearly revealed a direct relation between antioxidant potential and phenolic contents of CA\u2212H and CA\u2212C. In AChE and BChE inhibitory assay, CA\u2212H and CA\u2212E showed better inhibition (AChE: 8.24\u00b10.77 &amp; 4.46\u00b10.007\u2005mg GALAE\/g extract; BChE: 5.40\u00b10.02 &amp; 1.92\u00b10.24\u2005mg GALAE\/g extract) as compared to other fractions, whereas, against tyrosinase, CA\u2212B was most active (37.35\u00b10.53\u2005mg KAE\/g extract). CA\u2212H and CA\u2212C also showed higher inhibitory potential (0.98\u00b10.08 &amp; 0.58\u00b10.01\u2005mmol ACAE\/g extract) against \u03b1\u2010Amylase; while against \u03b1\u2010Glucosidase, CA\u2212E was the most active fraction. UHPLC\/MS analysis of the methanolic extract of <jats:italic>C. arvensis<\/jats:italic> disclosed the presence of 62 compounds as sterols, triterpenes, flavonoids, fatty acids, alkaloids and coumarins. In Multivariate Analysis, the total phenolic contents were correlated strongly with all antioxidant assays except FRAP and DPPH. Regarding enzyme inhibitory properties, only AChE, BChE and \u03b1\u2010amylase were correlated with the total phenolic contents in the extracts. Docking analyses confirmed these findings, as identified compounds had high binding free energy and inhibition constants with the enzymes studied. It was finally concluded that <jats:italic>C. arvensis<\/jats:italic> is a potential industrial crop, which can be a component of nutraceuticals and functional foods, if evaluated for its toxicity.<\/jats:p>","DOI":"10.1002\/cbdv.202200521","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:44:30Z","timestamp":1663944270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Total Bioactive Contents, Metabolic Profiling, Docking Studies, Antioxidant and Enzyme Inhibition Activities of <i>Convolvulus Arvensis<\/i> L. and Multivariate Analysis to Unravel a Potential Herb as Natural Resource for Pharmaceutical Industry"],"prefix":"10.1002","volume":"19","author":[{"given":"Muhammad","family":"Imran Tousif","sequence":"first","affiliation":[{"name":"Department of Chemistry Division of Science and Technology University of Education  54000 Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamona","family":"Nazir","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government Sadiq Women College University  Bahawalpur 63100-Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Saleem","sequence":"additional","affiliation":[{"name":"Division of Organic Chemistry Institute of Chemistry Baghdad-ul-Jadeed Campus The Islamia University of Bahawalpur  63100- Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Tauseef","sequence":"additional","affiliation":[{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research. 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