{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:50Z","timestamp":1786977350080,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573694"],"award-info":[{"award-number":["81573694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Liver is an important metabolic organ with numerous functions in human body. Hepatitis is defined as the inflammation of the liver tissue, which could lead to acute liver failure, liver fibrosis, liver cirrhosis and hepatocellular carcinoma.\n                    <jats:italic>Corydalis tomentella<\/jats:italic>\n                    Franch., a precious herb in China, is often used in the treatment of hepatitis, liver cirrhosis and liver cancer. In this study, 41 isoquinoline alkaloids and derivatives isolated by our lab from\n                    <jats:italic>C.\u2005tomentella<\/jats:italic>\n                    and 61 related targets were analyzed by network pharmacology. Their activities were further verified by cell assay evaluated for antitumor activity against HepG2 cells and molecular docking. The results confirmed that the alkaloids from\n                    <jats:italic>C.tomentella<\/jats:italic>\n                    had extensive hepatoprotective effects, and TNF\u2010\u03b1 was the key target of hendersinate B methyl ester against acute liver damage by viral hepatitis and HCC, which provided a foundation for further\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202200542","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T01:26:26Z","timestamp":1660267586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hepatoprotective Effect Associated with Alkaloids from\n                    <i>Corydalis tomentella<\/i>\n                    Franch. based on Network Pharmacology, Molecular Docking and\n                    <i>in Vitro<\/i>\n                    Experiment"],"prefix":"10.1002","volume":"19","author":[{"given":"Kunqi","family":"Zong","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhutong","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Songa","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-4916","authenticated-orcid":false,"given":"Dali","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.96553"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.01.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2221-1691.273081"},{"key":"e_1_2_8_5_1","first-page":"2467","article-title":"\u2018Discussion on the Major Ingredients and Targets of Shenchai Granules for the Hepatoprotective Based on Network Pharmacology\u2019","volume":"36","author":"Shen H.","year":"2019","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"e_1_2_8_6_1","first-page":"845","article-title":"\u2018Prediction of anti-hepatic fibrosis effect of Piperis Longi Fructus based on network pharmacology\u2019","volume":"46","author":"Zhang S. P.","year":"2021","journal-title":"Chin. J. Chin. Mater. Med."},{"key":"e_1_2_8_7_1","first-page":"44","article-title":"\u2018Study on Quality Standard of Corydalis tomentella Franch\u2019","volume":"9","author":"Wu J.","year":"2018","journal-title":"Med. 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