{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:47:47Z","timestamp":1783777667925,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the anticholinesterase effects of the extracts and isolated compounds from the roots of endemic <jats:italic>Prangos uechtritzii<\/jats:italic> Boiss &amp; Hausskn (Apiaceae) are reported. A novel polyacetylenic compound; (+)\u20108\u2010<jats:italic>O<\/jats:italic>\u2010methyloplopantriol A along with two known polyacetylenes; (\u2212)\u2010panaxynol, (+)\u2010falcarindiol and fifteen known coumarin derivatives; umbelliferone, 6\u2010formylumbelliferone, suberosin, 7\u2010demethylsuberosin, (+)\u2010ulopterol, tamarin, psoralen, imperatorin, (+)\u2010oxypeucedanin, (+)\u2010oxypeucedanin hydrate, (+)\u2010oxypeucedanin methanolate, (+)\u2010marmesin, (\u2212)\u2010prantschimgin, (+)\u2010decursinol, and (\u2212)\u2010adicardin were isolated from the hexane (Pu\u2010HE), chloroform (Pu\u2010CE), and methanol (Pu\u2010ME) extracts of <jats:italic>P.\u2005uechtritzii<\/jats:italic> roots. (\u2212)\u2010Panaxynol, (+)\u2010falcarindiol, 6\u2010formylumbelliferone, (+)\u2010decursinol, and (\u2212)\u2010adicardin were obtained from the genus <jats:italic>Prangos<\/jats:italic> for the first time. (+)\u20108\u2010<jats:italic>O<\/jats:italic>\u2010Methyloplopantriol A inhibited both AChE (IC<jats:sub>50<\/jats:sub>=194.5\u00b15.8\u2005\u03bcM) and BChE (IC<jats:sub>50<\/jats:sub>=51.9\u00b12.96\u2005\u03bcM) enzymes. (+)\u2010Falcarindiol, 6\u2010formylumbelliferone, 7\u2010demethylsuberosin, tamarin, and imperatorin also exhibited BChE\u2010specific inhibitory activities (IC<jats:sub>50<\/jats:sub>=27.88\u201093.86\u2005\u03bcM). (+)\u2010Falcarindiol (IC<jats:sub>50<\/jats:sub>=27.88\u00b10.91\u2005\u03bcM) and imperatorin (IC<jats:sub>50<\/jats:sub>=30.89\u00b11.40\u2005\u03bcM) as the most active components could be led compounds to develop new BChE inhibitors with further research against Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/cbdv.202200557","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:55:04Z","timestamp":1665071704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anticholinesterase Compounds from Endemic <i>Prangos uechtritzii<\/i>"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-0796","authenticated-orcid":false,"given":"Gokay","family":"Albayrak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy \u0130zmir Katip \u00c7elebi University  35620 \u0130zmir Turkey"},{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Ege University  35040 \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-8818","authenticated-orcid":false,"given":"Serdar","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Ege University  35040 \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-9894","authenticated-orcid":false,"given":"Halil","family":"Koyu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy \u0130zmir Katip \u00c7elebi University  35620 \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-4811","authenticated-orcid":false,"given":"Sura","family":"Baykan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Ege University  35040 \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/547153a"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.043"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202100294"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612461679"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202102082"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042915-103753"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610203008676"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12081"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.02.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311040004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1961138"},{"key":"e_1_2_9_14_1","first-page":"163","article-title":"\u2018An ethnopharmacological review on the Turkish Apiaceae species\u2019","volume":"44","author":"Bulut G.","year":"2014","journal-title":"J. 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