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In this article, the structure of curcumin was modified with boron trifluoride ether to change fluorescent labeling. The compounds were then embedded into the hydrophobic cavity of \u03b1\u2010cyclodextrin and hydroxypropyl \u03b2\u2010cyclodextrin to form inclusion complexes. The two inclusion complexes have excellent photophysical properties, and the maximum emission wavelength is in the range of 550\u2013565\u2005nm. In addition, the two compounds were applied to the fluorescence imaging of HCT\u2010116 cells and HeLa cells, and the proliferation toxicity of the compounds was detected. Both compounds showed certain inhibitory effects on the proliferation of cancer cells. In short, the fluorescent drug molecule synthesized in this article has great reference value for the development of new dosage forms of curcumin.<\/jats:p>","DOI":"10.1002\/cbdv.202200644","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T02:54:45Z","timestamp":1666752885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bioactivity and Cell Imaging of Antitumor Fluorescent Agents (Curcumin Derivatives) Coated by Two\u2010Way Embedded Cyclodextrin Strategy"],"prefix":"10.1002","volume":"19","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmacy Jiangsu University Zhenjiang 212013 P. R. China (G.F. Jin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaibo","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jiangsu University Zhenjiang 212013 P. R. China (G.F. 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