{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:42:03Z","timestamp":1758127323850,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups \u2013 (1) control group (C) administered interperitoneally with a single dose 0.9\u2009% saline, (2) Cis group administered a single dose (7\u2005mg\/kg) of cisplatin, (3) Sun group administered 10\u2005mg\/kg sunitinib for seven days, and (4) Cis+Sun group administered 10\u2005mg\/kg sunitinib for seven days after a single dose (7\u2005mg\/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1\u03b2 and TGF\u2010\u03b23 expression levels when administered alone; it increased ALT, AST, and IL\u201038 levels. When sunitinib was given to the cisplatin\u2010induced rats, it was observed that the increase in ALT, AST, and IL\u201038 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.<\/jats:p>","DOI":"10.1002\/cbdv.202200704","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T06:55:30Z","timestamp":1674802530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effects of Sunitinib in Healthy and Cisplatin\u2010Induced Rats"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-5648","authenticated-orcid":false,"given":"Levent","family":"Demirtas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Erzincan Binali Y\u0131ld\u0131r\u0131m University  24100 Erzincan T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-0587","authenticated-orcid":false,"given":"Mehmet","family":"G\u00fcrb\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Erzincan Binali Y\u0131ld\u0131r\u0131m University  24100 Erzincan T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-0073","authenticated-orcid":false,"given":"Emin Murat","family":"Akbas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Faculty of Medicine Erzincan Binali Y\u0131ld\u0131r\u0131m University  24100 Erzincan T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-0654","authenticated-orcid":false,"given":"Hilal","family":"Tahirler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine G\u00fclhane Training and Research Hospital Health Sciences University  06010 Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-8059","authenticated-orcid":false,"given":"Ozhan","family":"Karatas","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Faculty of Veterinary Medicine Sivas Cumhuriyet University  58140 Sivas T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-8569","authenticated-orcid":false,"given":"Yusuf","family":"Kemal Arslan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Medical Faculty \u00c7ukurova University  01330 Adana T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.010.10553"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11318860-000000000-00000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.02.156"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102925"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206933"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0392-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002786"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00257239"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.986005"},{"key":"e_1_2_10_11_1","first-page":"4049","article-title":"\u2018Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity\u2019","volume":"16","author":"Bilgic Y.","year":"2018","journal-title":"Exp. 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